| # | Name | Team | Opp | Date | Score | AB | H | RBI | HR | R | BB | GS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Daniel Fornes | LAD | STL | July 24, 2005 | 16-0 | 5 | 4 | 8 | 3 | 3 | 0 | 120 |
| 2 | Jorge Scuderi | CWS | CHC | May 20, 2005 | 11-10 | 6 | 5 | 7 | 2 | 3 | 0 | 116 |
| 3 | Alex Cardenas | TEX | OAK | Aug. 28, 2005 | 10-5 | 5 | 4 | 8 | 2 | 3 | 0 | 115 |
| 4 | Carlos Cruz | MIN | MIL | May 22, 2005 | 24-7 | 7 | 4 | 9 | 2 | 3 | 0 | 114 |
| 5 | Jose Reyes | BOS | BAL | May 16, 2005 | 24-5 | 6 | 5 | 3 | 2 | 6 | 1 | 114 |
| 6 | Shelley Duncan | KC | MIN | Aug. 5, 2005 | 11-4 | 5 | 4 | 6 | 3 | 4 | 0 | 113 |
| 7 | Rocco Baldelli | NYM | CHC | July 16, 2005 | 14-6 | 6 | 5 | 8 | 1 | 2 | 0 | 111 |
| 8 | Alfonso Carreiras | MIL | CIN | July 4, 2005 | 15-6 | 4 | 4 | 5 | 2 | 4 | 1 | 110 |
| 9 | Andruw Jones | BOS | BAL | May 16, 2005 | 24-5 | 7 | 5 | 6 | 1 | 4 | 0 | 107 |
| 10 | Daniel Fornes | LAD | PHI | June 5, 2005 | 8-11 | 3 | 3 | 7 | 2 | 2 | 2 | 107 |
| 11 | Ken Griffey Jr. | TOR | CWS | May 27, 2005 | 16-5 | 6 | 5 | 6 | 1 | 3 | 0 | 104 |
| 12 | Jong-su Shin | CIN | LAD | Aug. 3, 2005 | 6-9 | 4 | 4 | 5 | 2 | 3 | 1 | 103 |
| 13 | Rickie Weeks Jr. | WAS | COL | Sept. 8, 2005 | 15-16 | 3 | 2 | 7 | 2 | 3 | 2 | 102 |
| 14 | Will Ford | HOU | PIT | Aug. 26, 2005 | 15-2 | 6 | 4 | 4 | 3 | 5 | 0 | 102 |
| 15 | Gennaro Caruso | LAA | CWS | May 10, 2005 | 12-0 | 6 | 5 | 4 | 2 | 4 | 0 | 102 |
| 16 | Sam Penfold | STL | CHC | June 3, 2005 | 10-8 | 5 | 4 | 5 | 2 | 4 | 0 | 101 |
| 17 | Sam Penfold | STL | NYM | Aug. 23, 2005 | 8-7 | 5 | 4 | 6 | 2 | 3 | 0 | 101 |
| 18 | Esteban German | MIN | BOS | June 14, 2005 | 7-5 | 5 | 3 | 7 | 3 | 3 | 0 | 101 |
| 19 | Jong-su Shin | CIN | PIT | May 18, 2005 | 13-11 | 5 | 5 | 3 | 1 | 4 | 1 | 99 |
| 20 | Daniel Fornes | LAD | ATL | May 31, 2005 | 9-10 | 5 | 3 | 5 | 3 | 4 | 1 | 99 |
| 21 | Ryan Howard | LAA | TB | July 25, 2005 | 11-2 | 5 | 4 | 5 | 2 | 3 | 1 | 99 |
| 22 | Tony Clark | DET | BOS | Aug. 15, 2005 | 7-3 | 5 | 5 | 4 | 2 | 3 | 0 | 99 |
| 23 | Joe Mauer | SD | CHC | May 7, 2005 | 13-12 | 4 | 4 | 4 | 1 | 4 | 1 | 98 |
| 24 | Shawn Green | ATL | BAL | July 2, 2005 | 21-5 | 4 | 4 | 4 | 1 | 4 | 1 | 98 |
| 25 | Elias Preciado | PIT | ATL | Aug. 23, 2005 | 13-7 | 6 | 3 | 7 | 3 | 3 | 0 | 97 |
| 26 | Manny Ramirez | TB | NYY | Sept. 15, 2005 | 18-2 | 6 | 5 | 7 | 1 | 1 | 0 | 97 |
| 27 | Fernando Tatis | DET | CLE | May 14, 2005 | 13-1 | 4 | 4 | 4 | 2 | 3 | 1 | 96 |
| 28 | Josh Hamilton | OAK | TB | Sept. 11, 2005 | 11-7 | 4 | 4 | 4 | 2 | 3 | 1 | 96 |
| 29 | John Valentin | NYM | PHI | May 24, 2005 | 12-11 | 4 | 4 | 4 | 2 | 3 | 1 | 96 |
| 30 | Raul Romero | CIN | SF | Aug. 26, 2005 | 11-9 | 5 | 4 | 7 | 1 | 2 | 0 | 96 |