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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sakamoto, Haruki | LF | Ann Aardvarks | 25 | 01/01/2044 | Aomori | JPN | Right | Right | 6' 0" | 200 lbs | - |
| Salter, Cameron | RP | Fremont Farmers | 22 | 10/17/2047 | Sint Nicolas | ARU | Right | Right | 5' 9" | 165 lbs | - |
| Sancho, Amador | LF | Free Agent | 24 | 01/16/2045 | Brasília | BRA | Right | Right | 6' 2" | 200 lbs | - |
| Sarpaneva, Niko | RP | Charleston Shrimp N Grits | 25 | 10/25/2044 | Szentlorinc | HUN | Left | Right | 5' 9" | 170 lbs | $500,000 |
| Sato, Minoru | RP | Free Agent | 24 | 12/23/2045 | Ryuyo | JPN | Right | Right | 6' 7" | 200 lbs | - |
| Sato, Toshiki | RP | Charleston Shrimp N Grits | 25 | 12/18/2044 | Kashiwazaki | JPN | Left | Right | 6' 2" | 200 lbs | $500,000 |
| Schneider, Nate | 1B | Westeros White Walkers | 35 | 07/02/2034 | Unknown | USA | Right | Right | 6' 1" | 180 lbs | - |
| Schultz, Tom | RP | Free Agent | 37 | 05/04/2032 | Warner Robins | USA | Right | Right | 6' 2" | 195 lbs | - |
| Segura, Pedro | SS | Free Agent | 25 | 05/01/2044 | Mexico City | MEX | Right | Right | 6' 2" | 195 lbs | - |
| Serna, Pedro | SP | Zanarkand Abes | 30 | 11/09/2039 | Chihuahua | MEX | Left | Left | 5' 10" | 175 lbs | - |
| Seymour, Jim | RP | Cincinnati Grippos | 25 | 11/24/2044 | Meriden | USA | Right | Right | 6' 4" | 200 lbs | $500,000 |
| Skouloudis, Bemus | C | Zanarkand Abes | 25 | 09/12/2044 | Nicosia | CYP | Right | Right | 6' 1" | 200 lbs | - |
| Smith, George | 3B | Bloomington Buzzards | 23 | 04/28/2046 | Brooklyn | USA | Right | Right | 6' 1" | 180 lbs | - |
| Smith, Spike | RP | Portland Penguins | 22 | 05/28/2047 | Pocatello | USA | Right | Left | 6' 2" | 185 lbs | - |
| Smith, Will | SP | Cincinnati Grippos | 26 | 09/05/2043 | Painesville | USA | Left | Right | 6' 4" | 200 lbs | - |
| Snyder, Russell | SP | Caprica Buccaneers | 26 | 09/12/2043 | Lumberton | USA | Switch | Right | 6' 3" | 205 lbs | $500,000 |
| Solano, Alfredo | SP | Free Agent | 27 | 11/02/2042 | Santo Domingo | DOM | Left | Left | 6' 2" | 200 lbs | - |
| Solís, Carlos | C | Nibelheim Nosferatu | 24 | 09/23/2045 | Humacao | PUR | Right | Right | 6' 0" | 185 lbs | - |
| Soto, Gregory | LF | Cincinnati Grippos | 25 | 08/05/2044 | Austin | USA | Right | Left | 6' 6" | 200 lbs | - |
| Soto, José | SP | Caprica Buccaneers | 23 | 07/11/2046 | New York | USA | Right | Right | 6' 2" | 190 lbs | - |
| Soto, Valentín | RP | Omaha Wild Dogs | 35 | 09/11/2034 | Guantanamo | CUB | Left | Right | 6' 2" | 200 lbs | $1,300,000 |
| Spivey, Sherman | 3B | Charleston Shrimp N Grits | 29 | 06/03/2040 | Washington | USA | Right | Right | 6' 1" | 200 lbs | $1,527,605 |
| Stewart, Lawrence | 2B | Free Agent | 28 | 01/03/2041 | Pasadena | USA | Right | Right | 6' 1" | 200 lbs | - |
| Stokes, Ralph | RP | Ann Aardvarks | 26 | 12/11/2043 | Plainedge | USA | Left | Left | 6' 7" | 215 lbs | $500,000 |
| Subhi, Na'il | SP | Cincinnati Grippos | 24 | 03/19/2045 | Dzidri-I | COM | Right | Right | 6' 3" | 195 lbs | - |
| Suzuki, Osamu | 2B | Ann Aardvarks | 24 | 10/04/2045 | Osaka | JPN | Right | Right | 6' 3" | 200 lbs | $500,000 |
| Sánchez, Fernando | 2B | Free Agent | 27 | 09/12/2042 | Salem | USA | Right | Right | 6' 0" | 185 lbs | - |
| Sánchez, Germán | SP | Toledo Bullfrogs | 25 | 07/17/2044 | Redan | USA | Right | Right | 5' 10" | 185 lbs | - |
| Sánchez, Jesús | RF | Hermosa Beach Whales | 25 | 02/03/2044 | Santo Domingo | DOM | Right | Right | 6' 2" | 200 lbs | $500,000 |
| Sánchez, Juan | SP | Free Agent | 26 | 06/15/2043 | Azua | DOM | Left | Left | 5' 9" | 170 lbs | - |
