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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Zaldana, Franklin | 1B | Chicago Cubs | 17 | 12/22/2020 | Santo Domingo | DOM | Right | Right | 6' 2" | 200 lbs | - |
| Zambrano, Mike | SP | Toronto Blue Jays | 26 | 11/12/2011 | North Highlands | USA | Right | Right | 6' 0" | 190 lbs | $2,200,000 |
| Zambrano, Oscar | SS | St. Louis Cardinals | 17 | 08/06/2020 | Puerto Plata | DOM | Right | Right | 6' 1" | 170 lbs | - |
| Zamora, Alex | CF | Nashville Stars | 17 | 04/11/2020 | Arenoso | DOM | Right | Left | 6' 2" | 175 lbs | - |
| Zamora, Alex | RF | Houston Astros | 26 | 01/13/2012 | Decatur | USA | Right | Right | 6' 3" | 205 lbs | - |
| Zamora, David | SP | Minnesota Twins | 17 | 09/07/2020 | Valencia | VEN | Left | Left | 6' 4" | 190 lbs | - |
| Zamora, Jordan | SP | San Diego Padres | 25 | 06/30/2012 | Santiago | DOM | Right | Right | 6' 1" | 185 lbs | $570,500 |
| Zamora, Melvin | CF | Free Agent | 27 | 09/24/2010 | Doctor Phillips | USA | Left | Right | 5' 10" | 185 lbs | - |
| Zamora, Rich | CF | Portland Loggers | 17 | 04/28/2020 | Falcon | VEN | Right | Left | 6' 0" | 180 lbs | - |
| Zamorano, Mike | LF | Washington Nationals | 25 | 02/18/2013 | Santo Domingo | DOM | Right | Right | 6' 2" | 195 lbs | $570,500 |
| Zanatti, Altifício | RP | San Diego Padres | 18 | 10/01/2019 | Cascavel | BRA | Right | Right | 5' 11" | 160 lbs | - |
| Zapata, Joaquin | SP | Toronto Blue Jays | 17 | 02/17/2021 | Neyba | DOM | Switch | Right | 6' 6" | 190 lbs | - |
| Zapata, Jorge | SP | Minnesota Twins | 19 | 09/01/2018 | Santiago | PAN | Right | Right | 6' 0" | 170 lbs | - |
| Zapata, Tony | LF | Free Agent | 15 | 09/12/2022 | Cypress | USA | Right | Right | 6' 0" | 170 lbs | - |
| Zatarain, Vinny | CF | Los Angeles Dodgers | 18 | 09/18/2019 | Huetamo | MEX | Left | Left | 6' 1" | 200 lbs | - |
| Zavala, Franklin | CF | San Francisco Giants | 28 | 01/09/2010 | San Pedro de Macorís | DOM | Left | Left | 6' 0" | 200 lbs | - |
| Zavala, Jorge | SP | Detroit Tigers | 25 | 07/27/2012 | Santo Domingo | DOM | Right | Right | 6' 2" | 200 lbs | - |
| Zavala, Julio | 3B | Tampa Bay Rays | 17 | 06/30/2020 | Santo Domingo | DOM | Right | Right | 6' 1" | 185 lbs | - |
| Zavala, Omar | RP | Boston Red Sox | 16 | 05/10/2021 | La Vega | DOM | Right | Right | 6' 2" | 175 lbs | - |
| Zavala, Samuel | LF | Free Agent | 33 | 07/15/2004 | Caracas | VEN | Left | Left | 6' 1" | 200 lbs | - |
| Zavala, Tony | 3B | Portland Loggers | 17 | 03/05/2021 | Jagüey Grande | CUB | Right | Right | 6' 2" | 180 lbs | - |
| Zazueta, Edgar | C | Washington Nationals | 17 | 05/29/2020 | Santo Domingo | DOM | Right | Right | 6' 4" | 200 lbs | - |
| Zazueta, Felix | 2B | Chicago Cubs | 18 | 04/14/2019 | Puerto Cabello | VEN | Right | Right | 5' 11" | 155 lbs | - |
| Zegri, Alvare | SP | Washington Nationals | 17 | 12/19/2020 | Barcelona | VEN | Left | Right | 6' 2" | 170 lbs | - |
| Zeiler, Manfred | 3B | Free Agent | 16 | 07/02/2021 | Vienna | AUT | Right | Right | 6' 1" | 180 lbs | - |
| Zelensky, Jonathan | SP | Tampa Bay Rays | 22 | 06/18/2015 | Southern Pines | USA | Right | Right | 6' 4" | 195 lbs | - |
| Zepeda, Manny | SP | Arizona Diamondbacks | 18 | 06/07/2019 | La Vega | DOM | Right | Right | 6' 2" | 175 lbs | - |
| Ziegler, Mike | RP | Los Angeles Angels | 24 | 12/31/2013 | New York | USA | Right | Right | 6' 4" | 205 lbs | $570,500 |
| Zier, Rusty | LF | Free Agent | 19 | 04/10/2018 | Jonesboro | USA | Switch | Left | 6' 0" | 185 lbs | - |
| Zuluaga, Bill | SP | Toronto Blue Jays | 19 | 06/16/2018 | San Pedro de Macorís | DOM | Switch | Right | 6' 3" | 185 lbs | - |
| Zuluaga, Rich | SS | Philadelphia Phillies | 23 | 03/12/2015 | Haltom City | USA | Right | Right | 6' 2" | 185 lbs | - |
| Zumaya, Hector | RP | Free Agent | 21 | 07/13/2016 | Carolina | PUR | Right | Right | 6' 1" | 185 lbs | - |
| Zumbado, Oscar | RP | Free Agent | 17 | 11/14/2020 | Henrietta | USA | Switch | Right | 6' 4" | 180 lbs | - |
| Zunich, Chris | 2B | Free Agent | 17 | 04/12/2020 | Houston | USA | Right | Right | 6' 5" | 185 lbs | - |
| Zuniga, Omar | CF | San Diego Padres | 16 | 12/16/2021 | San Juan de la Maguana | DOM | Right | Right | 6' 4" | 180 lbs | - |
| Zuniga, Tony | RP | Cincinnati Reds | 17 | 10/17/2020 | Matamoros | MEX | Right | Right | 6' 0" | 165 lbs | - |
| Zurak, Chris | SP | Arizona Diamondbacks | 25 | 02/26/2013 | Buffalo | USA | Right | Right | 6' 2" | 190 lbs | $570,500 |
| Zurita, Alex | RP | Free Agent | 17 | 09/10/2020 | Sacramento | USA | Right | Right | 6' 5" | 190 lbs | - |
| Zwartbol, Mauk | SP | San Diego Padres | 18 | 05/19/2019 | Paramaribo | SUR | Switch | Right | 6' 3" | 190 lbs | - |
