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| Wednesday, April 22nd , 2043 |
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| Detroit (DSL) Tigers 1: Released RP Jesus Castillo. |
| Detroit (DSL) Tigers 1: Released RP Juan Aparicio. |
| Tuesday, April 14th , 2043 |
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| Cleveland (DSL) Guardians Blue: Released 2B Jorge Pineda. |
| Cleveland (DSL) Guardians Blue: Released RP Luis Lagares. |
| Cleveland (DSL) Guardians Red: Released RF Ignacio Zarate. |
| Cleveland (DSL) Guardians Red: Released RP Juan Ortega. |
| Cleveland (DSL) Guardians Blue: Released C Juan Ramirez. |
| Monday, April 13th , 2043 |
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| Seattle (DSL) Mariners: Released SP Juan Rodarte. |
| Seattle (DSL) Mariners: Released C Ken Rose. |
| Seattle (DSL) Mariners: Released 1B Jorge Tinajero. |
| Seattle (DSL) Mariners: Released 2B Edgar Rubalcava. |
| Friday, April 10th , 2043 |
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| Detroit (DSL) Tigers 1: Released RP Alfredo Trevino. |
| Miami (DSL) Marlins 2: Placed SP Luis Vallecillo on the active roster. |
| Thursday, April 2nd , 2043 |
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| Baltimore (DSL) Orioles Orange: Received RF Ernesto Rayo from the international complex. |
| Baltimore (DSL) Orioles Orange: Received 2B Ezequiel Ortega from the international complex. |
| Tampa Bay (DSL) Rays 2: Received SS Edgar Salazar from the international complex. |
| Tampa Bay (DSL) Rays 2: Received SP Gregorio Iraheta from the international complex. |
| Toronto (DSL) Blue Jays: Received C David Romero from the international complex. |
| Cleveland (DSL) Guardians Red: Received SP Edgar Morales from the international complex. |
| Cleveland (DSL) Guardians Red: Received RP Jesus Mandujano from the international complex. |
| Detroit (DSL) Tigers 1: Received SP Jorge Bucio from the international complex. |
| Detroit (DSL) Tigers 2: Received C Gilberto Solares from the international complex. |
| Detroit (DSL) Tigers 1: Received C David Vega from the international complex. |
| Minnesota (DSL) Twins: Received SP Frank Nieves from the international complex. |
| Minnesota (DSL) Twins: Received SP Alejandro Neria from the international complex. |
| Seattle (DSL) Mariners: Received SS Humberto Contreras from the international complex. |
| Washington (DSL) Nationals: Received C Alejandro Blanco from the international complex. |
| Washington (DSL) Nationals: Received SP Andres Viera from the international complex. |
| Pittsburgh (DSL) Pirates Black: Received SP Julio Orozco from the international complex. |
| Pittsburgh (DSL) Pirates Gold: Received SP Luis Zamora from the international complex. |
| Pittsburgh (DSL) Pirates Black: Received CF Jesus Segura from the international complex. |
| Pittsburgh (DSL) Pirates Gold: Received 2B Julio Morales from the international complex. |
| Arizona (DSL) Diamondbacks Red: Received CF Juan Anzures from the international complex. |
| Arizona (DSL) Diamondbacks Red: Received CF Virgílio Vaccarini from the international complex. |
| San Francisco (DSL) Giants Black: Received C Alfredo Estorga from the international complex. |
| Detroit (DSL) Tigers 2: Released SP Danny Gillis. |
| Friday, March 27th , 2043 |
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| Toronto (DSL) Blue Jays: Released RP Juan Bravo. |
| Thursday, March 5th , 2043 |
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| Cleveland (DSL) Guardians Red: Released RP Jorge Saldana. |
| Monday, March 2nd , 2043 |
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| Minnesota (DSL) Twins: Released RP David Maldonado. |
| Saturday, February 28th , 2043 |
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| Detroit (DSL) Tigers 1: Released LF Jorge Guereca. |
| Thursday, February 26th , 2043 |
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| Baltimore (DSL) Orioles Orange: Received RF Saul Salinas from the international complex. |
| Baltimore (DSL) Orioles Orange: Received CF Juan Vela from the international complex. |
| Baltimore (DSL) Orioles Orange: Received 3B Jorge Flores from the international complex. |
| Baltimore (DSL) Orioles Black: Received SS Luis Cerros from the international complex. |
| Baltimore (DSL) Orioles Orange: Received SP Sergio Luna from the international complex. |
| Baltimore (DSL) Orioles Black: Received SP Mauricio Castillo from the international complex. |
| Baltimore (DSL) Orioles Orange: Received SP David de los Santos from the international complex. |
| Baltimore (DSL) Orioles Black: Received SP Luis Morales from the international complex. |
| Baltimore (DSL) Orioles Orange: Received SP Luis Brambila from the international complex. |
| Baltimore (DSL) Orioles Black: Received SS Arturo Montenegro from the international complex. |
| Baltimore (DSL) Orioles Orange: Received SP Daniel Arango from the international complex. |
| Tampa Bay (DSL) Rays 2: Received CF Amadeu Frazo from the international complex. |
| Tampa Bay (DSL) Rays 2: Received SP Rodolfo Mata from the international complex. |
| Tampa Bay (DSL) Rays 2: Received SP Sergio Salinas from the international complex. |
| Toronto (DSL) Blue Jays: Received CF Julio Prado from the international complex. |
| Toronto (DSL) Blue Jays: Received SP Daniel Cordona from the international complex. |
| Toronto (DSL) Blue Jays: Received SS Alejandro Silva from the international complex. |
| Toronto (DSL) Blue Jays: Received CL Sergio Curiel from the international complex. |
| Toronto (DSL) Blue Jays: Received SP Ignacio Bautista from the international complex. |
| Toronto (DSL) Blue Jays: Received SP Arturo de la Paz from the international complex. |
| Chicago A (DSL) White Sox: Received SP Vincent Vergara from the international complex. |
| Cleveland (DSL) Guardians Blue: Received RP Jesus Romero from the international complex. |
| Cleveland (DSL) Guardians Blue: Received C Ignacio San Miguel from the international complex. |
| Cleveland (DSL) Guardians Blue: Received 2B Juan Tejeda from the international complex. |
| Cleveland (DSL) Guardians Red: Received CF Luis Ramirez from the international complex. |
| Cleveland (DSL) Guardians Blue: Received SS Juan Suniga from the international complex. |
| Cleveland (DSL) Guardians Red: Received SS Sergio Rosales from the international complex. |
| Cleveland (DSL) Guardians Blue: Received SP David Castillo from the international complex. |
| Cleveland (DSL) Guardians Red: Received SP Andres Villegas from the international complex. |
| Cleveland (DSL) Guardians Blue: Received SP Juan Villasenor from the international complex. |
| Cleveland (DSL) Guardians Red: Received SP Luis Salazar from the international complex. |
| Cleveland (DSL) Guardians Blue: Received SP Jesus Quintero from the international complex. |
| Cleveland (DSL) Guardians Red: Received SP Jorge Flores from the international complex. |
| Detroit (DSL) Tigers 2: Received 2B Vito Cabrera from the international complex. |
| Detroit (DSL) Tigers 2: Received SP Alexis Hinojosa from the international complex. |
| Detroit (DSL) Tigers 2: Received C Arturo Cardena from the international complex. |
| Detroit (DSL) Tigers 2: Received SP Frank Ibarra from the international complex. |
| Detroit (DSL) Tigers 1: Received RP Juan Vargas from the international complex. |
| Kansas City (DSL) Royals Glass: Received SS Federico Tapia from the international complex. |
| Minnesota (DSL) Twins: Received C Edgar Castillo from the international complex. |
| Minnesota (DSL) Twins: Received SP Juan Montoya from the international complex. |
| Minnesota (DSL) Twins: Received SP Juan Loaiza from the international complex. |
| Minnesota (DSL) Twins: Received C Jesus Fragoso from the international complex. |
| Minnesota (DSL) Twins: Received SS Edgar Badillo from the international complex. |
| Minnesota (DSL) Twins: Received CF Jesus Valiente from the international complex. |
| Minnesota (DSL) Twins: Received SS Juan Estrada from the international complex. |
| Minnesota (DSL) Twins: Received SS Santiago Laobardo from the international complex. |
| Minnesota (DSL) Twins: Received SP Frank Luna from the international complex. |
| Minnesota (DSL) Twins: Received RP Gilberto Cotto from the international complex. |
| Seattle (DSL) Mariners: Received RF Alfredo Alisto from the international complex. |
| Texas (DSL) Rangers Red: Received RF Wilfredo Cisneros from the international complex. |
| Washington (DSL) Nationals: Received 1B Jesus Bonilla from the international complex. |
| Washington (DSL) Nationals: Received 2B Ismael Aguilar from the international complex. |
| Washington (DSL) Nationals: Received SP Juan Morales from the international complex. |
| Washington (DSL) Nationals: Received SP Jesus Ramon from the international complex. |
| Washington (DSL) Nationals: Received SP Jesus Vera from the international complex. |
| Cincinnati (DSL) Reds: Received SP Luis Villa from the international complex. |
| Cincinnati (DSL) Reds: Received SP Frank Soto from the international complex. |
| Pittsburgh (DSL) Pirates Black: Received SS Sergio Vigil from the international complex. |
| Pittsburgh (DSL) Pirates Black: Received C Luis Cabrera from the international complex. |
| Pittsburgh (DSL) Pirates Gold: Received SP Abraham Oceguera from the international complex. |
| Pittsburgh (DSL) Pirates Black: Received SP Alejandro Quijada from the international complex. |
| Pittsburgh (DSL) Pirates Gold: Received SP Ezequiel Corvera from the international complex. |
| Pittsburgh (DSL) Pirates Black: Received SP Jesus Borges from the international complex. |
| Pittsburgh (DSL) Pirates Gold: Received SP Andres Quintana from the international complex. |
| Pittsburgh (DSL) Pirates Black: Received RP Daniel Alfaro from the international complex. |
| St. Louis (DSL) Cardinals: Received SP Frank Adame from the international complex. |
| St. Louis (DSL) Cardinals: Received SS Luis Lara from the international complex. |
| Arizona (DSL) Diamondbacks Red: Received SP Marino Lozano from the international complex. |
| Arizona (DSL) Diamondbacks Red: Received CF Vincent Guerrero from the international complex. |
| Arizona (DSL) Diamondbacks Red: Received SP David Bravo from the international complex. |
| San Diego (DSL) Padres: Received SP Isidro Savala from the international complex. |
| San Diego (DSL) Padres: Received SP Hsi-chuen Thian from the international complex. |
| San Diego (DSL) Padres: Received SP Cândido Tavernard from the international complex. |
| San Francisco (DSL) Giants Black: Received CF Ramiro Vargas from the international complex. |
| San Francisco (DSL) Giants Black: Received SP Luis Montes from the international complex. |
| San Francisco (DSL) Giants Black: Received SP Daniel Peraza from the international complex. |
| Thursday, January 15th , 2043 |
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| Seattle (DSL) Mariners: Received C David Mercedes from the international complex. |
| Tuesday, January 13th , 2043 |
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| Toronto (DSL) Blue Jays: Released LF Edgar Ledezma. |
| Toronto (DSL) Blue Jays: Released 1B Nate Sisca. |
| Tuesday, January 6th , 2043 |
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| Toronto (DSL) Blue Jays: Released RP Jesus Ayala. |
| Saturday, January 3rd , 2043 |
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| Seattle (DSL) Mariners: Received SP Celestino Giusto from the international complex. |
