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| Name | W | L | SV | ERA | G | GS | IP | HA | R | ER | HR | BB | K | WHIP | OAVG | BABIP | WAR |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dave Elder RP | 1 | 0 | 11 | 1.65 | 17 | 0 | 16.1 | 12 | 3 | 3 | 1 | 6 | 20 | 1.10 | .211 | .306 | 0.6 |
| Danny Borne RP | 0 | 0 | 0 | 2.08 | 5 | 0 | 4.1 | 1 | 1 | 1 | 0 | 5 | 6 | 1.38 | .071 | .111 | 0.1 |
| Gio Gonzalez SP | 4 | 1 | 0 | 3.02 | 11 | 11 | 62.2 | 48 | 21 | 21 | 7 | 18 | 64 | 1.05 | .213 | .266 | 1.4 |
| Fernando Hernandez RP | 1 | 3 | 12 | 3.13 | 23 | 0 | 23.0 | 19 | 12 | 8 | 2 | 7 | 26 | 1.13 | .221 | .293 | 0.6 |
| Mark Buehrle RP | 0 | 0 | 0 | 3.24 | 7 | 0 | 8.1 | 8 | 3 | 3 | 1 | 3 | 3 | 1.32 | .242 | .241 | -0.1 |
| Heath Castle RP | 3 | 2 | 2 | 3.52 | 51 | 0 | 61.1 | 48 | 28 | 24 | 7 | 24 | 61 | 1.17 | .212 | .255 | 0.5 |
| Zach Frachiseur RP | 4 | 2 | 0 | 3.82 | 56 | 0 | 66.0 | 63 | 31 | 28 | 6 | 28 | 64 | 1.38 | .247 | .305 | 0.8 |
| Justin James SP | 5 | 4 | 5 | 4.21 | 50 | 3 | 87.2 | 82 | 42 | 41 | 10 | 31 | 102 | 1.29 | .243 | .313 | 1.5 |
| Carlos Morales SP | 11 | 5 | 0 | 4.27 | 21 | 21 | 139.0 | 134 | 77 | 66 | 8 | 71 | 160 | 1.47 | .250 | .336 | 3.5 |
| Joe Martinez SP | 10 | 8 | 0 | 4.63 | 25 | 25 | 161.1 | 156 | 90 | 83 | 24 | 55 | 174 | 1.31 | .250 | .306 | 2.6 |
| J.D. Martin SP | 5 | 9 | 5 | 4.66 | 37 | 20 | 137.0 | 131 | 77 | 71 | 22 | 37 | 138 | 1.23 | .248 | .294 | 1.4 |
| Dustin Moseley RP | 0 | 0 | 0 | 5.06 | 5 | 0 | 5.1 | 5 | 3 | 3 | 1 | 2 | 8 | 1.31 | .238 | .333 | 0.0 |
| Jensen Lewis SP | 9 | 8 | 0 | 5.20 | 30 | 30 | 164.1 | 156 | 100 | 95 | 12 | 73 | 172 | 1.39 | .250 | .325 | 3.7 |
| Jake Peavy RP | 2 | 3 | 0 | 5.34 | 33 | 5 | 91.0 | 87 | 54 | 54 | 21 | 34 | 99 | 1.33 | .255 | .296 | -0.3 |
| Ross Ohlendorf SP | 8 | 10 | 0 | 5.83 | 29 | 29 | 143.2 | 174 | 98 | 93 | 20 | 75 | 142 | 1.73 | .298 | .360 | 1.3 |
| Dan Smith CL | 6 | 8 | 8 | 5.87 | 54 | 0 | 53.2 | 64 | 36 | 35 | 9 | 25 | 57 | 1.66 | .292 | .357 | -0.1 |
| Mike Parisi RP | 1 | 0 | 2 | 7.71 | 7 | 0 | 7.0 | 8 | 6 | 6 | 1 | 2 | 10 | 1.43 | .276 | .389 | 0.1 |
| Ehren Wassermann RP | 7 | 3 | 1 | 8.48 | 61 | 0 | 63.2 | 80 | 67 | 60 | 4 | 51 | 81 | 2.06 | .297 | .411 | 0.4 |
