| # | Name | Team | Opp | Date | Score | AB | H | RBI | HR | R | BB | GS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Walt Messer | NYG | PIT | Sept. 21, 1950 | 9-3 | 5 | 4 | 6 | 4 | 4 | 0 | 118 |
| 2 | Denny Andrews | CIN | MON | May 17, 1950 | 11-4 | 5 | 5 | 4 | 2 | 5 | 0 | 113 |
| 3 | Don Berry | PHI | PIT | Aug. 20, 1950 | 14-12 | 6 | 4 | 7 | 2 | 4 | 0 | 111 |
| 4 | Tim Hopkins | CHI | BOS | June 4, 1950 | 13-3 | 5 | 4 | 8 | 2 | 2 | 0 | 108 |
| 5 | Tony Mullis | DET | PIT | May 17, 1950 | 18-6 | 5 | 4 | 7 | 2 | 3 | 0 | 108 |
| 6 | Fred Miller | BRK | NYS | Sept. 3, 1950 | 12-6 | 5 | 4 | 7 | 2 | 3 | 0 | 108 |
| 7 | Sherry Doyal | CLE | TOR | Sept. 28, 1950 | 11-5 | 5 | 5 | 6 | 1 | 2 | 1 | 106 |
| 8 | Kirby Copeland | TOR | PHS | May 30, 1950 | 11-1 | 4 | 4 | 6 | 2 | 3 | 0 | 105 |
| 9 | Newt Cooper | NYS | TOR | Aug. 5, 1950 | 16-0 | 4 | 4 | 4 | 2 | 3 | 2 | 101 |
| 10 | Les Cunha | PHS | TOR | May 30, 1950 | 10-7 | 4 | 4 | 6 | 1 | 3 | 0 | 100 |
| 11 | Irv Clifford | PIT | NYG | July 16, 1950 | 19-8 | 6 | 5 | 6 | 0 | 3 | 0 | 99 |
| 12 | Pete Casstevens | CHI | WAS | July 26, 1950 | 10-2 | 5 | 4 | 5 | 3 | 3 | 0 | 99 |
| 13 | Walt Messer | NYG | PIT | Sept. 20, 1950 | 15-7 | 6 | 5 | 6 | 1 | 2 | 0 | 97 |
| 14 | Dick Estes | DET | CHI | May 26, 1950 | 6-5 | 4 | 4 | 5 | 2 | 2 | 1 | 96 |
| 15 | Joe Read | PIT | STL | July 14, 1950 | 23-1 | 4 | 4 | 4 | 1 | 3 | 2 | 96 |
| 16 | Hank Koblenz | PHI | CHI | Aug. 27, 1950 | 9-6 | 3 | 3 | 6 | 2 | 2 | 1 | 95 |
| 17 | George Cleaves | NYG | CLE | Oct. 8, 1950 | 18-3 | 5 | 5 | 4 | 1 | 3 | 0 | 94 |
| 18 | Bunny Hufford | NYG | WAS | May 23, 1950 | 18-11 | 4 | 3 | 4 | 0 | 5 | 2 | 93 |
| 19 | Lorenzo Samuels | CLE | NYS | Aug. 23, 1950 | 16-10 | 3 | 3 | 3 | 2 | 4 | 2 | 93 |
| 20 | Roosevelt Brewer | NYG | CLE | Oct. 8, 1950 | 18-3 | 6 | 4 | 5 | 1 | 4 | 0 | 92 |
| 21 | Bobby Barrell | PHI | WAS | June 27, 1950 | 14-3 | 4 | 4 | 2 | 1 | 5 | 1 | 91 |
| 22 | Billy Woytek | PHI | NYG | June 24, 1950 | 10-0 | 3 | 3 | 7 | 1 | 1 | 1 | 90 |
| 23 | Jesse Alvardo | WAS | CHI | Aug. 25, 1950 | 16-1 | 5 | 4 | 5 | 0 | 3 | 1 | 89 |
| 24 | Hank Koblenz | PHI | WAS | June 27, 1950 | 14-3 | 5 | 3 | 6 | 2 | 3 | 0 | 89 |
| 25 | John Jackson | CLE | CIN | Aug. 16, 1950 | 15-4 | 4 | 4 | 6 | 0 | 2 | 0 | 88 |
| 26 | Rudy Minton | PHI | CHI | Aug. 27, 1950 | 9-6 | 3 | 3 | 3 | 1 | 4 | 2 | 88 |
| 27 | Billy Dalton | BOS | PIT | July 4, 1950 | 9-4 | 5 | 4 | 4 | 2 | 3 | 0 | 87 |
| 28 | Dick Estes | DET | BOS | Sept. 19, 1950 | 8-5 | 5 | 5 | 5 | 1 | 1 | 0 | 87 |
| 29 | Billy Woytek | PHI | BOS | Sept. 6, 1950 | 15-4 | 5 | 4 | 3 | 1 | 4 | 1 | 87 |
| 30 | Red Johnson | NYG | PIT | Sept. 19, 1950 | 7-6 | 5 | 4 | 4 | 2 | 3 | 0 | 87 |