| # | Name | Team | Opp | Date | Score | AB | H | RBI | HR | R | BB | GS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Chuck Lewis | KCK | SFS | Aug. 20, 1959 | 10-9 | 5 | 4 | 7 | 3 | 4 | 0 | 120 |
| 2 | Dave Price | CHI | DET | May 14, 1959 | 20-3 | 6 | 4 | 8 | 2 | 4 | 0 | 118 |
| 3 | Frank Selander | PIT | DET | Sept. 7, 1959 | 12-2 | 5 | 5 | 5 | 1 | 4 | 1 | 113 |
| 4 | Jerry Smith | STL | PHI | May 3, 1959 | 7-5 | 4 | 3 | 6 | 3 | 3 | 1 | 103 |
| 5 | Mickey Tucker | CHI | WAS | May 28, 1959 | 12-5 | 6 | 5 | 5 | 1 | 3 | 1 | 102 |
| 6 | Ken Newman | KCK | SFS | July 12, 1959 | 13-1 | 5 | 4 | 7 | 2 | 2 | 0 | 101 |
| 7 | Buddy Miller | PHI | DET | May 30, 1959 | 14-4 | 6 | 3 | 7 | 3 | 3 | 0 | 97 |
| 8 | Charlie Ham | CIN | CLE | May 20, 1959 | 15-1 | 6 | 4 | 6 | 2 | 3 | 0 | 97 |
| 9 | Ralph Barrell | LAS | MON | Aug. 12, 1959 | 10-7 | 3 | 3 | 6 | 2 | 3 | 0 | 97 |
| 10 | John Low | CLE | LAS | Sept. 9, 1959 | 15-2 | 5 | 4 | 6 | 1 | 3 | 0 | 96 |
| 11 | Bill Newhall | PIT | NYG | Aug. 12, 1959 | 11-10 | 4 | 4 | 4 | 2 | 3 | 1 | 96 |
| 12 | Lloyd Coulter | PHI | PIT | Sept. 22, 1959 | 11-2 | 3 | 3 | 5 | 2 | 3 | 1 | 95 |
| 13 | Armando Estrada | PHI | WAS | May 14, 1959 | 11-5 | 5 | 5 | 4 | 1 | 3 | 0 | 94 |
| 14 | Hank Estill | NYG | PIT | April 11, 1959 | 17-2 | 5 | 3 | 6 | 2 | 3 | 1 | 94 |
| 15 | William Buttry | LAS | KCK | May 24, 1959 | 14-4 | 5 | 4 | 6 | 2 | 2 | 0 | 94 |
| 16 | Jerry Smith | STL | DET | June 27, 1959 | 12-2 | 5 | 4 | 4 | 2 | 4 | 0 | 94 |
| 17 | Tom Carr | CLE | KCK | June 17, 1959 | 15-2 | 5 | 4 | 5 | 1 | 3 | 1 | 94 |
| 18 | Jerry McMillan | CHC | SFS | Sept. 2, 1959 | 6-0 | 5 | 5 | 3 | 1 | 4 | 0 | 94 |
| 19 | Rex Pilcher | NYG | CHI | June 27, 1959 | 15-1 | 5 | 4 | 5 | 1 | 3 | 1 | 94 |
| 20 | Joe Kleman | BOS | PHI | June 15, 1959 | 12-1 | 4 | 4 | 5 | 1 | 3 | 0 | 93 |
| 21 | Ken Newman | KCK | SFS | June 19, 1959 | 7-5 | 4 | 3 | 5 | 2 | 3 | 1 | 91 |
| 22 | Joe Reed | DET | STL | June 17, 1959 | 12-4 | 4 | 4 | 4 | 1 | 3 | 1 | 91 |
| 23 | Hank Williams | KCK | CLE | Sept. 15, 1959 | 9-6 | 4 | 3 | 4 | 2 | 4 | 1 | 91 |
| 24 | Dixie Williams | TOR | KCK | July 19, 1959 | 15-6 | 4 | 4 | 5 | 1 | 2 | 1 | 91 |
| 25 | Johnny Elliot | CIN | KCK | April 25, 1959 | 10-8 | 7 | 4 | 4 | 3 | 4 | 0 | 91 |
| 26 | Hal Kennedy | CLE | LAS | Sept. 9, 1959 | 15-2 | 3 | 3 | 4 | 1 | 4 | 1 | 90 |
| 27 | Earl Howe | NYG | BOS | Sept. 10, 1959 | 9-4 | 5 | 3 | 7 | 2 | 2 | 0 | 89 |
| 28 | Jim Baccari | WAS | PIT | June 26, 1959 | 14-13 | 5 | 3 | 6 | 1 | 3 | 1 | 89 |
| 29 | Edwin Hackberry | SFS | LAS | July 14, 1959 | 16-4 | 3 | 2 | 4 | 2 | 4 | 2 | 88 |
| 30 | Mickey Tucker | CHI | WAS | July 2, 1959 | 23-6 | 5 | 3 | 5 | 1 | 3 | 2 | 87 |