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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sabuio, Rufino | SP | Erie SeaWolves | 23 | 12/06/2047 | São José dos Pinhais | BRA | Left | Left | 6' 3" | 185 lbs | - |
| Salazar, Felipe | RF | Northwest Arkansas Naturals | 22 | 02/24/2049 | Penn Hills | USA | Switch | Left | 5' 11" | 175 lbs | - |
| Saldivar, Mario | LF | Jackson Generals | 24 | 12/20/2046 | Quetzaltenango | GUA | Switch | Right | 6' 4" | 200 lbs | - |
| Salmela, Ylermi | 1B | Free Agent | 27 | 02/18/2044 | Lahti | FIN | Switch | Right | 6' 2" | 205 lbs | - |
| Salvenmoser, Josef | RP | Jacksonville Suns | 23 | 01/29/2048 | Leonding | AUT | Right | Right | 6' 4" | 195 lbs | - |
| Samim, Eski | C | Free Agent | 27 | 11/06/2043 | Konya | TUR | Switch | Right | 6' 2" | 200 lbs | - |
| Sanders, Jesse | 1B | San Antonio Missions | 26 | 03/01/2045 | Morrisville | USA | Right | Right | 6' 4" | 200 lbs | - |
| Sanders, Lyle | 2B | Free Agent | 25 | 08/07/2045 | Toronto | CAN | Right | Right | 6' 0" | 200 lbs | - |
| Sandoval, Francis | RP | Binghamton Rumble Ponies | 25 | 11/11/2045 | Courtland | USA | Right | Right | 6' 0" | 195 lbs | - |
| Sandoval, Román | CF | Huntsville Stars | 19 | 05/08/2052 | Wichita | USA | Right | Left | 6' 3" | 180 lbs | - |
| Sandoval, Wilfried | RF | Richmond Flying Squirrels | 23 | 10/24/2047 | Sint Nicolas | ARU | Left | Left | 6' 6" | 200 lbs | - |
| Sano, Keitaro | RP | Free Agent | 27 | 11/14/2043 | Tokyo | JPN | Right | Right | 6' 8" | 200 lbs | - |
| Santana, Manny | SP | Free Agent | 29 | 06/28/2042 | Veracruz | MEX | Right | Left | 6' 1" | 200 lbs | - |
| Santos, Domingo | CF | Pensacola Blue Wahoos | 23 | 08/19/2047 | Laredo | USA | Left | Left | 6' 2" | 195 lbs | - |
| Santos, Jaime | C | Free Agent | 26 | 04/04/2045 | Sint Nicolas | ARU | Right | Right | 6' 2" | 200 lbs | - |
| Santos, Luis | CF | Northwest Arkansas Naturals | 21 | 12/29/2049 | Auburn | USA | Switch | Right | 6' 2" | 185 lbs | - |
| Santry, Bob | RP | Arkansas Travelers | 24 | 02/08/2047 | Garland | USA | Right | Right | 6' 2" | 195 lbs | - |
| Saracino, Alex | CF | Altoona Curve | 24 | 02/11/2047 | White Oak | USA | Right | Right | 6' 3" | 200 lbs | - |
| Sato, Kyoden | SP | Pensacola Blue Wahoos | 28 | 08/02/2042 | Fukagawa | JPN | Right | Right | 6' 0" | 195 lbs | - |
| Schied, Lewis | 1B | Free Agent | 26 | 01/09/2045 | Nuremberg | GER | Right | Right | 6' 4" | 200 lbs | - |
| Schilder, Jamy | SS | Arkansas Travelers | 25 | 11/03/2045 | Wymbritseradiel | NED | Right | Right | 6' 1" | 200 lbs | - |
| Schimmerhorn, Millard | RF | Portland Sea Dogs | 24 | 09/13/2046 | Fort Wayne | USA | Left | Left | 6' 4" | 200 lbs | - |
| Schlotterbeck, Warner | SS | Erie SeaWolves | 22 | 10/23/2048 | Hameln | GER | Right | Right | 6' 1" | 175 lbs | - |
| Scott, Cody | 1B | Mississippi Braves | 25 | 02/16/2046 | Elizabethtown | USA | Left | Left | 6' 2" | 200 lbs | - |
| Scott, Lou | LF | Free Agent | 27 | 07/19/2044 | Blaine | USA | Right | Left | 6' 4" | 200 lbs | - |
| Segem, Basir | 1B | New Hampshire Fisher Cats | 25 | 02/03/2046 | Izmir | TUR | Left | Left | 6' 2" | 200 lbs | - |
| Segers, Quentin | 1B | Altoona Curve | 21 | 11/04/2049 | Amsterdam | NED | Switch | Right | 6' 1" | 195 lbs | - |
| Seiberling, Rupert | RP | New Hampshire Fisher Cats | 24 | 02/01/2047 | Berlin | GER | Right | Right | 6' 1" | 180 lbs | - |
| Sepos, Políbio | CF | Bowie Baysox | 26 | 10/04/2044 | Curitiba | BRA | Right | Right | 6' 1" | 200 lbs | $490,000 |
| Sharaev, Fadey | 1B | Midland RockHounds | 27 | 06/05/2044 | Kirovohrad | UKR | Right | Right | 6' 1" | 200 lbs | - |
| Sheahan, Rickey | SP | Birmingham Barons | 26 | 07/06/2045 | Massapequa | USA | Right | Right | 6' 2" | 195 lbs | - |
| Shinohara, Kohei | RP | Jackson Generals | 26 | 08/22/2044 | Gifu | JPN | Left | Left | 5' 9" | 185 lbs | - |
| Short, Jeff | SS | Huntsville Stars | 19 | 05/13/2052 | Lecanto | USA | Right | Right | 6' 4" | 175 lbs | - |
| Sicak, Arnost | SP | Free Agent | 27 | 06/14/2044 | Ceské Budejovice | CZE | Switch | Right | 6' 7" | 200 lbs | - |
| Sier, Godfrey | SP | Mobile BayBears | 26 | 09/19/2044 | Schijndel | NED | Right | Right | 5' 10" | 180 lbs | - |
| Sierra, Duane | SP | Arkansas Travelers | 22 | 07/10/2049 | Brea | USA | Right | Left | 6' 2" | 170 lbs | - |
| Silva, António | 2B | Northwest Arkansas Naturals | 23 | 11/12/2047 | Santiago | CHI | Right | Right | 6' 2" | 200 lbs | - |
| Silva, Miguel | SP | Montgomery Biscuits | 24 | 09/04/2046 | Carolina | PUR | Right | Right | 6' 2" | 195 lbs | - |
| Simmons, Conner | 1B | Tennessee Smokies | 23 | 06/24/2048 | North Ogden | USA | Right | Right | 6' 6" | 200 lbs | - |
| Simmons, Mal | SP | Mississippi Braves | 23 | 10/23/2047 | Jacksonville | USA | Right | Right | 6' 1" | 180 lbs | - |
| Simpson, Richard | LF | Jackson Generals | 21 | 07/07/2050 | Riverdale | USA | Switch | Right | 6' 2" | 180 lbs | - |
| Skalde, Herbert | RF | Tulsa Drillers | 28 | 01/16/2043 | Trinec | CZE | Left | Left | 6' 1" | 195 lbs | $490,000 |
| Skarba, Woldemar | C | Birmingham Barons | 24 | 08/18/2046 | Deblin | POL | Right | Right | 6' 2" | 210 lbs | - |
| Slaughter, Alex | 3B | Free Agent | 26 | 02/20/2045 | San Francisco | USA | Right | Right | 6' 0" | 200 lbs | - |
| Slooters, Gerard | SP | Bowie Baysox | 27 | 02/17/2044 | Amsterdam | NED | Right | Right | 6' 3" | 200 lbs | - |
| Smallbridge, Leon | CF | Chattanooga Lookouts | 23 | 11/14/2047 | Boca Del Mar | USA | Left | Left | 6' 1" | 195 lbs | - |
| Smith, Mike | SP | New Hampshire Fisher Cats | 20 | 11/07/2050 | Brooklyn | USA | Right | Right | 6' 1" | 180 lbs | - |
| Smith, Ray | CL | Tulsa Drillers | 26 | 01/17/2045 | Lakeland | USA | Right | Right | 6' 6" | 200 lbs | - |
| Snider, Les | C | Portland Sea Dogs | 22 | 10/07/2048 | Paradise | USA | Right | Right | 6' 2" | 200 lbs | - |
| Snyder, Matt | RF | Chattanooga Lookouts | 22 | 03/22/2049 | Redmond | USA | Right | Right | 6' 3" | 185 lbs | - |
| So Romo, Faustino | 3B | Tennessee Smokies | 20 | 10/12/2050 | Paranagua | BRA | Left | Right | 6' 2" | 185 lbs | - |
| Sofian, Saghir | C | Altoona Curve | 24 | 12/31/2046 | Mazar-e Sarif | AFG | Right | Right | 6' 0" | 200 lbs | - |
| Soledade, Gabriel | SS | Mobile BayBears | 23 | 02/25/2048 | Mogi Guaçu | BRA | Right | Right | 6' 0" | 190 lbs | - |
| Solís, Roberto | CF | Binghamton Rumble Ponies | 24 | 03/08/2047 | Barcelona | ESP | Left | Right | 6' 2" | 200 lbs | - |
| Solíz, Miguel | C | New Britain Rock Cats | 26 | 06/07/2045 | San Francisco de Macorís | DOM | Left | Right | 5' 10" | 200 lbs | - |
| Soriano, José | SS | Jackson Generals | 24 | 09/30/2046 | Los Angeles | USA | Right | Right | 6' 4" | 200 lbs | - |
| Soto, António | RF | Free Agent | 27 | 04/26/2044 | Bogota | COL | Left | Left | 6' 2" | 200 lbs | - |
| Southcott, Jules | RF | Midland RockHounds | 24 | 04/03/2047 | Ottawa | CAN | Right | Right | 6' 0" | 195 lbs | - |
| Spencer, John | C | Montgomery Biscuits | 25 | 04/27/2046 | Webster | USA | Right | Right | 6' 2" | 200 lbs | - |
| Stanford, Stephen | RP | Tulsa Drillers | 25 | 09/23/2045 | Loyal | USA | Right | Right | 6' 0" | 170 lbs | - |
| Steengrafe, Tom | SP | Richmond Flying Squirrels | 28 | 09/21/2042 | Los Angeles | USA | Right | Right | 6' 1" | 200 lbs | - |
| Stephens, Dennis | 3B | Free Agent | 26 | 01/22/2045 | Long Beach | USA | Right | Right | 6' 2" | 200 lbs | - |
| Stewart, Riley | LF | Free Agent | 25 | 04/05/2046 | Albuquerque | USA | Left | Left | 6' 3" | 200 lbs | - |
| Stokes, Abraham | LF | Free Agent | 27 | 05/15/2044 | Brookline | USA | Left | Left | 6' 1" | 200 lbs | - |
| Stokes, Ryan | SP | Mississippi Braves | 24 | 03/18/2047 | Overland Park | USA | Right | Right | 6' 6" | 200 lbs | - |
| Stone, Richard | SP | Huntsville Stars | 24 | 07/28/2046 | Tucker | USA | Left | Left | 6' 5" | 200 lbs | - |
| Swanson, Jerome | SP | Frisco RoughRiders | 22 | 08/31/2048 | Modesto | USA | Right | Right | 6' 1" | 185 lbs | - |
| Sykes, John | SP | Montgomery Biscuits | 22 | 10/16/2048 | Little Falls | USA | Left | Left | 6' 8" | 195 lbs | - |
| Sánchez, Andrés | 2B | Arkansas Travelers | 23 | 12/24/2047 | Petorca | CHI | Switch | Right | 6' 2" | 190 lbs | - |
| Sánchez, Carlos | LF | Arkansas Travelers | 22 | 01/15/2049 | Esperanza | CUB | Right | Right | 6' 5" | 200 lbs | - |
| Sánchez, Felipe | RP | Free Agent | 25 | 10/27/2045 | Villa Nueva | GUA | Right | Right | 6' 6" | 200 lbs | - |
| Sánchez, Jesús | SP | Corpus Christi Hooks | 22 | 08/26/2048 | Denver | USA | Right | Right | 6' 5" | 200 lbs | - |
| Sánchez, José | SS | Altoona Curve | 21 | 06/10/2050 | Villavicencio | COL | Left | Right | 6' 4" | 185 lbs | - |
