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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saintlouis, Nazir | SP | Salem Red Sox | 24 | 12/29/2019 | New York | USA | Left | Left | 6' 2" | 200 lbs | - |
| Salyards, Sam | RF | Carolina Mudcats | 23 | 10/04/2020 | Jersey City | USA | Left | Left | 6' 1" | 200 lbs | - |
| Sammarco, Mike | LF | Free Agent | 26 | 09/05/2017 | Ft. Wayne | USA | Left | Right | 6' 4" | 200 lbs | - |
| Sanchez, Alvaro | LF | Fayetteville Woodpeckers | 22 | 09/22/2021 | San Cristóbal | CUB | Right | Right | 6' 0" | 210 lbs | - |
| Sanchez, Danny | SP | Frederick Keys | 27 | 08/14/2017 | Tocumen | PAN | Right | Right | 6' 7" | 200 lbs | - |
| Sanchez, Omar | SP | Winston-Salem Dash | 23 | 07/07/2021 | Utuado | PUR | Left | Left | 6' 1" | 190 lbs | - |
| Sanders, Dave | RP | Free Agent | 26 | 07/02/2018 | Ft. Wright | USA | Right | Right | 6' 0" | 185 lbs | - |
| Santana, Marco | RF | Lynchburg Hillcats | 27 | 02/21/2017 | Kendall | USA | Right | Right | 6' 4" | 205 lbs | - |
| Saylor, Dan | RP | Fayetteville Woodpeckers | 25 | 02/09/2019 | Fremont | USA | Right | Right | 6' 9" | 200 lbs | - |
| Schultz, Eric | CF | Myrtle Beach Pelicans | 24 | 06/21/2020 | Bend | USA | Left | Right | 6' 5" | 200 lbs | - |
| Schwartz, Jonathan | 3B | Winston-Salem Dash | 23 | 04/28/2021 | Albuquerque | USA | Right | Right | 6' 2" | 195 lbs | $590,000 |
| Scroggins, Robby | SP | Lynchburg Hillcats | 24 | 05/21/2020 | Ft. Lauderdale | USA | Left | Left | 6' 2" | 200 lbs | - |
| Segovia, Victor | RP | Winston-Salem Dash | 23 | 09/06/2020 | Farmington Hills | USA | Left | Left | 6' 4" | 200 lbs | - |
| Sepulveda, Mike | RP | Carolina Mudcats | 25 | 10/04/2018 | New Smyrna Beach | USA | Left | Right | 6' 1" | 190 lbs | - |
| Shaw, Danny | RP | Carolina Mudcats | 24 | 09/02/2019 | Salisbury | USA | Left | Left | 6' 2" | 200 lbs | - |
| Shih, Jing-sheng | RP | Free Agent | 24 | 01/29/2020 | Yangmei | TPE | Right | Right | 6' 3" | 200 lbs | - |
| Shippen, Josh | SP | Wilmington Blue Rocks | 23 | 11/11/2020 | Cincinnati | USA | Switch | Right | 6' 3" | 195 lbs | - |
| Shurlow, Joe | SP | Wilmington Blue Rocks | 24 | 04/22/2020 | North Lindenhurst | USA | Right | Right | 5' 11" | 165 lbs | - |
| Sims, Danny | 1B | Lynchburg Hillcats | 26 | 05/06/2018 | Fremont | USA | Left | Left | 6' 1" | 195 lbs | - |
| Sirota, Bobby | 2B | Fredericksburg Nationals | 22 | 11/15/2021 | Gladstone | USA | Right | Right | 6' 6" | 200 lbs | - |
| Solomon, Kevin | LF | Myrtle Beach Pelicans | 24 | 05/17/2020 | Buffalo | USA | Left | Left | 6' 3" | 200 lbs | - |
| Sotelo, Federico | RP | Wilmington Blue Rocks | 25 | 11/19/2018 | Santo Domingo | DOM | Right | Right | 6' 0" | 185 lbs | - |
| Steadman, Mike | RP | Fayetteville Woodpeckers | 25 | 02/04/2019 | Mullins | USA | Left | Right | 6' 4" | 200 lbs | - |
| Stiles, Danny | 3B | Carolina Mudcats | 27 | 07/14/2017 | Jacksonville | USA | Right | Right | 6' 2" | 205 lbs | $590,000 |
| Stoner, Mike | 3B | Down East Wood Ducks | 26 | 02/24/2018 | Brighton | USA | Right | Right | 6' 1" | 205 lbs | - |
