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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sala, Laurenço | SP | Fredericksburg Nationals | 21 | 07/19/2019 | Barcelona | VEN | Left | Left | 6' 2" | 190 lbs | - |
| Salazar, Danny | C | Down East Wood Ducks | 26 | 01/18/2015 | Denver | USA | Right | Right | 6' 0" | 200 lbs | - |
| Salazar, Juan | CF | Down East Wood Ducks | 24 | 07/30/2016 | Nampa | USA | Left | Left | 6' 2" | 195 lbs | - |
| Salazar, Juan | SP | Down East Wood Ducks | 29 | 11/16/2011 | Santo Domingo | DOM | Right | Right | 6' 4" | 200 lbs | - |
| Salgado, Danny | C | Free Agent | 23 | 02/05/2018 | Antón | PAN | Right | Right | 6' 4" | 205 lbs | - |
| Sampson, Josh | SP | Fayetteville Woodpeckers | 20 | 01/17/2021 | Temecula | USA | Right | Right | 6' 6" | 190 lbs | - |
| Sanchez, Jose | 3B | Fredericksburg Nationals | 25 | 01/22/2016 | Bayamón | PUR | Right | Right | 6' 0" | 200 lbs | - |
| Sandys, Kevin | RF | Free Agent | 25 | 06/27/2015 | Brooklyn | USA | Left | Left | 6' 1" | 200 lbs | - |
| Santana, Marco | RF | Lynchburg Hillcats | 24 | 02/21/2017 | Kendall | USA | Right | Right | 6' 4" | 190 lbs | - |
| Schaan, Ian | LF | Free Agent | 26 | 05/11/2015 | Silver Spring | USA | Switch | Right | 6' 2" | 195 lbs | - |
| Schiffer, Josh | SP | Fredericksburg Nationals | 21 | 06/30/2019 | Santa Rosa | USA | Left | Left | 6' 1" | 180 lbs | - |
| Sears, D.J. | 2B | Frederick Keys | 20 | 06/30/2020 | Coral Springs | USA | Right | Right | 6' 1" | 170 lbs | - |
| Secaida, Manny | 2B | Lynchburg Hillcats | 25 | 09/20/2015 | Lumpkin | USA | Right | Right | 6' 3" | 200 lbs | - |
| Sellick, Tim | RP | Carolina Mudcats | 21 | 08/28/2019 | Sydney | AUS | Right | Right | 6' 5" | 195 lbs | - |
| Sepulveda, Mike | SP | Carolina Mudcats | 22 | 10/04/2018 | New Smyrna Beach | USA | Left | Right | 6' 1" | 180 lbs | - |
| Sharpton, Dan | RP | Frederick Keys | 23 | 10/01/2017 | Edison | USA | Right | Right | 6' 2" | 190 lbs | - |
| Shibuya, Rinji | CF | Fredericksburg Nationals | 27 | 01/07/2014 | Saitama | JPN | Right | Right | 6' 2" | 200 lbs | - |
| Shipman, Bob | 1B | Free Agent | 26 | 11/29/2014 | Jacksonville | USA | Left | Left | 6' 4" | 200 lbs | - |
| Shutts, Sam | CF | Fayetteville Woodpeckers | 24 | 05/02/2017 | Evergreen Park | USA | Right | Right | 6' 3" | 200 lbs | - |
| Sierra, Angelo | RP | Winston-Salem Dash | 24 | 08/31/2016 | Carolina | PUR | Right | Right | 6' 3" | 200 lbs | - |
| Smith, Brandon | 2B | Wilmington Blue Rocks | 26 | 03/14/2015 | Flushing | USA | Switch | Right | 6' 1" | 195 lbs | - |
| Solomon, Anthony | 2B | Frederick Keys | 20 | 05/16/2021 | Woodbridge | USA | Left | Right | 6' 3" | 185 lbs | - |
| Solorio, Ricky | RP | Fayetteville Woodpeckers | 25 | 06/25/2015 | Mayagüez | PUR | Right | Right | 6' 4" | 200 lbs | - |
| Stahley, Andy | 2B | Down East Wood Ducks | 27 | 01/01/2014 | Spanish Lake | USA | Right | Right | 5' 11" | 195 lbs | - |
| Staten, Danny | CF | Carolina Mudcats | 27 | 12/22/2013 | Brooklyn | USA | Right | Left | 6' 2" | 200 lbs | - |
| Stephanos, Steve | SP | Free Agent | 27 | 11/08/2013 | Milan | USA | Left | Right | 6' 8" | 200 lbs | - |
| Stern, Geoff | 1B | Lynchburg Hillcats | 23 | 09/29/2017 | Cincinnati | USA | Switch | Right | 6' 1" | 200 lbs | - |
| Stewart, Art | CF | Fayetteville Woodpeckers | 21 | 06/07/2019 | Las Cruces | USA | Right | Right | 6' 3" | 190 lbs | - |
| Strachan, Joe | C | Lynchburg Hillcats | 25 | 03/14/2016 | Los Angeles | USA | Right | Right | 6' 1" | 200 lbs | - |
| Straight, Chris | CF | Lynchburg Hillcats | 26 | 09/24/2014 | San Jose | USA | Right | Left | 6' 1" | 200 lbs | - |
| Stutler, Mike | C | Lynchburg Hillcats | 23 | 05/30/2017 | Hillside | USA | Switch | Right | 6' 1" | 190 lbs | - |
| Sykes, Andy | RP | Wilmington Blue Rocks | 21 | 06/17/2019 | West Norriton | USA | Left | Right | 6' 3" | 180 lbs | - |
