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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saenz, Dustin | SP | Harrisburg Senators | 25 | 06/02/1999 | Corpus Christi | USA | Left | Left | 5' 11" | 200 lbs | - |
| Sampen, Caleb | RP | Richmond Flying Squirrels | 28 | 07/23/1996 | Brownsburg | USA | Right | Right | 6' 2" | 185 lbs | - |
| Sanchez, Jose | 3B | Harrisburg Senators | 24 | 07/12/2000 | Villa de Cura | VEN | Right | Right | 5' 11" | 165 lbs | - |
| Santos, Angeudis | 2B | Binghamton Rumble Ponies | 23 | 09/19/2001 | Santiago | DOM | Switch | Right | 6' 1" | 175 lbs | - |
| Sarita, Erickson | LF | Richmond Flying Squirrels | 22 | 11/09/2002 | Unknown | DOM | Left | Left | 5' 7" | 145 lbs | - |
| Schultz, Paxton | SP | New Hampshire Fisher Cats | 27 | 01/05/1998 | Orem | USA | Left | Right | 6' 3" | 205 lbs | - |
| Scott, Adam | RP | Akron RubberDucks | 29 | 10/10/1995 | Canandaigua | USA | Left | Left | 6' 4" | 220 lbs | - |
| Sevilla, Jehisbert | 2B | Reading Fightin Phils | 21 | 03/21/2003 | Maracay | VEN | Right | Right | 5' 11" | 155 lbs | - |
| Shackelford, Aaron | 2B | Altoona Curve | 28 | 10/16/1996 | Murrieta | USA | Left | Right | 5' 10" | 205 lbs | - |
| Shaver, AJ | RF | Reading Fightin Phils | 23 | 10/08/2001 | Clermont | USA | Right | Right | 6' 2" | 220 lbs | - |
| Shawver, Evan | SP | Hartford Yard Goats | 25 | 09/11/1999 | Amherst | USA | Right | Left | 6' 0" | 180 lbs | - |
| Shore, Logan | SP | Free Agent | 30 | 12/28/1994 | Coon Rapids | USA | Right | Right | 6' 2" | 210 lbs | - |
| Shugart, Chase | RP | Portland Sea Dogs | 28 | 10/24/1996 | Bridge City | USA | Left | Right | 5' 10" | 190 lbs | - |
| Shuman, Seth | RP | Harrisburg Senators | 27 | 12/01/1997 | Spring Lake Park | USA | Right | Right | 6' 1" | 200 lbs | - |
| Silva, Eric | RP | Richmond Flying Squirrels | 22 | 10/03/2002 | Laguna Beach | USA | Right | Right | 6' 0" | 190 lbs | - |
| Simpson, Colin | 1B | Hartford Yard Goats | 28 | 07/23/1996 | Edmond | USA | Left | Right | 5' 9" | 230 lbs | - |
| Siri, Jose | CF | Hartford Yard Goats | 29 | 07/22/1995 | Sabana Grande de Boya | DOM | Right | Right | 6' 2" | 175 lbs | - |
| Smith, Dylan | SP | Erie SeaWolves | 24 | 05/28/2000 | Stafford | USA | Right | Right | 6' 2" | 185 lbs | - |
| Sosa, Andres | 2B | New Hampshire Fisher Cats | 27 | 11/07/1997 | Hermosillo | MEX | Right | Right | 5' 11" | 190 lbs | - |
| Spain, Garrett | RF | New Hampshire Fisher Cats | 24 | 09/21/2000 | Clarksville | USA | Left | Right | 5' 11" | 185 lbs | - |
| Stevenson, Andrew | CF | Somerset Patriots | 30 | 06/01/1994 | Lafayette | USA | Left | Left | 6' 0" | 195 lbs | - |
| Stovall, Hunter | 2B | Hartford Yard Goats | 28 | 09/05/1996 | Pelham | USA | Right | Right | 5' 8" | 175 lbs | - |
| Stratton, Hunter | RP | Altoona Curve | 28 | 11/17/1996 | Bristol | USA | Right | Right | 6' 4" | 225 lbs | - |
| Stumbo, Peyton | SP | Altoona Curve | 22 | 07/27/2002 | Auburn | USA | Right | Right | 6' 1" | 200 lbs | - |
| Suarez, Joander | RP | Binghamton Rumble Ponies | 25 | 02/27/2000 | Unknown | VEN | Right | Right | 6' 3" | 195 lbs | - |
| Sullivan, Liam | SP | Harrisburg Senators | 22 | 05/16/2002 | Sandy Springs | USA | Left | Left | 6' 6" | 245 lbs | - |
| Swiney, Nick | SP | Richmond Flying Squirrels | 26 | 02/12/1999 | Raleigh | USA | Right | Left | 6' 3" | 185 lbs | - |
| Szykowny, Charlie | 3B | Richmond Flying Squirrels | 24 | 06/30/2000 | Colorado Springs | USA | Left | Right | 6' 4" | 225 lbs | - |
