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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sabato, Aaron | 1B | St. Paul Saints | 25 | 06/04/1999 | Rye Brook | USA | Right | Right | 6' 2" | 225 lbs | - |
| Sabol, Blake | LF | Indianapolis Indians | 27 | 01/07/1998 | Aliso Viejo | USA | Left | Right | 6' 4" | 205 lbs | - |
| Salazar, Eduardo | RP | Memphis Redbirds | 26 | 05/05/1998 | Cumana | VEN | Right | Right | 6' 2" | 185 lbs | - |
| Sanchez, Angel | SP | Free Agent | 35 | 11/28/1989 | Tenares | DOM | Switch | Right | 6' 1" | 200 lbs | - |
| Sanchez, Lolo | LF | Rochester Red Wings | 25 | 04/23/1999 | Santo Domingo | DOM | Right | Right | 5' 11" | 180 lbs | - |
| Sanchez, Mario | RP | Durham Bulls | 30 | 10/31/1994 | Maracaibo | VEN | Right | Right | 6' 1" | 165 lbs | - |
| Sanchez, Ricardo | SP | Worcester Red Sox | 27 | 04/11/1997 | Puerto Cabello | VEN | Left | Left | 5' 11" | 215 lbs | - |
| Sanchez, Yolbert | 2B | Norfolk Tides | 27 | 03/03/1997 | Havana | CUB | Right | Right | 5' 11" | 185 lbs | - |
| Santana, Luis | 2B | Toledo Mud Hens | 25 | 07/20/1999 | Baní | DOM | Right | Right | 5' 8" | 180 lbs | - |
| Santos, Victor | SP | Worcester Red Sox | 24 | 07/12/2000 | Villa Tapia | DOM | Right | Right | 6' 1" | 200 lbs | - |
| Sauer, Matt | SP | Scranton WB RailRiders | 26 | 01/21/1999 | Santa Maria | USA | Right | Right | 6' 4" | 200 lbs | - |
| Schneemann, Daniel | 2B | Free Agent | 28 | 01/23/1997 | Chula Vista | USA | Left | Right | 6' 1" | 185 lbs | - |
| Schoenle, Garrett | RP | Charlotte Knights | 26 | 06/21/1998 | Fort Wayne | USA | Left | Left | 6' 5" | 200 lbs | - |
| Schoop, Jonathan | 2B | Worcester Red Sox | 33 | 10/16/1991 | Willemstad | CUR | Right | Right | 6' 1" | 225 lbs | - |
| Schulfer, Austin | SP | St. Paul Saints | 29 | 12/22/1995 | Plover | USA | Right | Right | 6' 2" | 180 lbs | - |
| Schultz, Andrew | CL | Lehigh Valley IronPigs | 27 | 07/31/1997 | Alpharetta | USA | Right | Right | 6' 4" | 195 lbs | - |
| Schweitzer, Tyler | RP | Charlotte Knights | 24 | 09/19/2000 | Fishers | USA | Left | Left | 6' 1" | 180 lbs | - |
| Scott, Connor | CF | Indianapolis Indians | 25 | 10/08/1999 | Tampa | USA | Left | Left | 6' 4" | 190 lbs | - |
| Scott, Stephen | C | Worcester Red Sox | 27 | 05/23/1997 | Cary | USA | Left | Right | 5' 11" | 200 lbs | - |
| Sears, Ben | RP | Omaha Storm Chasers | 24 | 06/15/2000 | Providence | USA | Right | Right | 6' 5" | 200 lbs | - |
| Segovia, Eduar | SP | Lehigh Valley IronPigs | 24 | 01/10/2001 | Valencia | VEN | Right | Right | 6' 0" | 185 lbs | - |
| Segura, Jean | 2B | Syracuse Mets | 34 | 03/17/1990 | Río San Juan | DOM | Right | Right | 5' 10" | 200 lbs | - |
| Sellers, Donnie | RP | Buffalo Bisons | 29 | 07/26/1995 | High Point | USA | Right | Right | 6' 1" | 195 lbs | - |
| Seminaris, Adam | SP | Nashville Sounds | 26 | 10/19/1998 | Chino Hills | USA | Right | Left | 6' 0" | 180 lbs | - |
| Serretti, Danny | SS | Toledo Mud Hens | 24 | 05/07/2000 | Berkeley Heights | USA | Switch | Right | 6' 0" | 190 lbs | - |
| Sheets, Gavin | 1B | Charlotte Knights | 28 | 04/23/1996 | Lutherville-Timonium | USA | Left | Left | 6' 5" | 230 lbs | - |
| Shuffield, Dalton | 2B | St. Paul Saints | 25 | 03/31/1999 | Tallahassee | USA | Right | Right | 5' 10" | 170 lbs | - |
| Simas, Kohl | SP | Charlotte Knights | 25 | 12/22/1999 | Fresno | USA | Right | Right | 6' 1" | 190 lbs | - |
| Simmons, Kendall | 3B | Lehigh Valley IronPigs | 24 | 04/11/2000 | Macon | USA | Right | Right | 6' 2" | 190 lbs | - |
| Sisco, Chance | C | Free Agent | 30 | 02/24/1995 | Corona | USA | Left | Right | 6' 2" | 195 lbs | - |
| Sisk, Evan | RP | Omaha Storm Chasers | 27 | 04/23/1997 | Chester | USA | Left | Left | 6' 2" | 210 lbs | - |
| Skirrow, Noah | SP | Lehigh Valley IronPigs | 26 | 07/21/1998 | Hamilton | CAN | Right | Right | 6' 3" | 210 lbs | - |
| Slaughter, Jake | 1B | Iowa Cubs | 28 | 10/24/1996 | Monroe | USA | Right | Right | 6' 3" | 200 lbs | - |
| Smith, Cade | RP | Columbus Clippers | 25 | 05/09/1999 | Abbotsford | CAN | Right | Right | 6' 5" | 225 lbs | - |
| Smyly, Drew | SP | Free Agent | 35 | 06/13/1989 | Little Rock | USA | Left | Left | 6' 3" | 190 lbs | - |
| Sogard, Nick | 3B | Worcester Red Sox | 27 | 09/09/1997 | Sacramento | USA | Switch | Right | 6' 1" | 180 lbs | - |
| Solak, Nick | 2B | Gwinnett Stripers | 30 | 01/11/1995 | Woodridge | USA | Right | Right | 5' 11" | 200 lbs | - |
| Solometo, Anthony | SP | Indianapolis Indians | 22 | 12/02/2002 | Winslow Township | USA | Left | Left | 6' 4" | 200 lbs | - |
| Song, Noah | SP | Worcester Red Sox | 27 | 05/28/1997 | Claremont | USA | Right | Right | 6' 4" | 200 lbs | - |
| Spacke, Dylan | RP | Worcester Red Sox | 26 | 03/11/1998 | San Diego | USA | Switch | Right | 6' 0" | 185 lbs | - |
| Sparkman, Glenn | SP | Free Agent | 32 | 05/11/1992 | Ganado | USA | Right | Right | 6' 2" | 205 lbs | - |
| Speas, Alex | RP | Omaha Storm Chasers | 26 | 03/04/1998 | Powder Springs | USA | Right | Right | 6' 4" | 190 lbs | - |
| Spence, Mitch | SP | Scranton WB RailRiders | 26 | 05/06/1998 | Cary | USA | Right | Right | 6' 1" | 190 lbs | - |
| Sprinkle, Jordan | 2B | Charlotte Knights | 23 | 03/06/2001 | Indio | USA | Right | Right | 5' 10" | 180 lbs | - |
| Stallings, Garrett | RP | Norfolk Tides | 27 | 08/08/1997 | Chesapeake | USA | Right | Right | 6' 2" | 200 lbs | - |
| Stankiewicz, John | RP | St. Paul Saints | 26 | 09/08/1998 | Cherry Hill | USA | Right | Right | 6' 4" | 220 lbs | - |
| Stassi, Max | C | Free Agent | 33 | 03/15/1991 | Woodland | USA | Right | Right | 5' 10" | 200 lbs | - |
| Stauffer, Adam | SP | Free Agent | 26 | 01/13/1999 | Coatesville | USA | Right | Right | 6' 7" | 240 lbs | - |
| Staumont, Josh | RP | Free Agent | 31 | 12/21/1993 | La Mirada | USA | Right | Right | 6' 3" | 195 lbs | - |
| Stephens, Jordan | RP | Nashville Sounds | 32 | 09/12/1992 | Alvin | USA | Right | Right | 6' 1" | 200 lbs | - |
| Stevenson, Cal | RF | Lehigh Valley IronPigs | 28 | 09/12/1996 | Fremont | USA | Left | Left | 5' 10" | 175 lbs | - |
| Stewart, Brock | RP | St. Paul Saints | 33 | 10/03/1991 | Normal | USA | Left | Right | 6' 3" | 215 lbs | - |
| Stewart, DJ | RF | Free Agent | 31 | 11/30/1993 | Yulee | USA | Left | Right | 6' 0" | 225 lbs | - |
| Stockton, Spencer | RP | Louisville Bats | 28 | 04/24/1996 | Wellington | USA | Switch | Right | 6' 3" | 200 lbs | - |
| Stoffal, Jace | RP | St. Paul Saints | 22 | 07/19/2002 | Roseburg | USA | Right | Right | 6' 3" | 210 lbs | - |
| Stoudt, Levi | RP | Louisville Bats | 27 | 12/04/1997 | Greenville | USA | Right | Right | 6' 1" | 200 lbs | - |
| Strong, Alan | SP | Nashville Sounds | 28 | 10/22/1996 | San Diego | USA | Right | Right | 6' 3" | 200 lbs | - |
| Suarez, Ranger | SP | Syracuse Mets | 29 | 08/26/1995 | Carora | VEN | Left | Left | 6' 1" | 180 lbs | - |
| Swaggerty, Travis | CF | Charlotte Knights | 27 | 08/19/1997 | Denham Springs | USA | Left | Left | 5' 11" | 190 lbs | - |
| Syndergaard, Noah | RP | Syracuse Mets | 32 | 08/29/1992 | Mansfield | USA | Left | Right | 6' 6" | 240 lbs | - |
