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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salazar, Omar | CF | Cedar Rapids Kernels | 27 | 07/04/2006 | La Guaira | VEN | Right | Right | 6' 0" | 180 lbs | - |
| Salinas, Jordan | CL | Free Agent | 25 | 12/10/2007 | Barquisimeto | VEN | Right | Right | 6' 0" | 185 lbs | - |
| Salter, Chris | SP | Wisconsin Timber Rattlers | 24 | 09/30/2009 | The Hammocks | USA | Right | Right | 6' 6" | 205 lbs | - |
| Sammons, Dan | SP | Free Agent | 31 | 01/04/2002 | Aurora | USA | Right | Right | 6' 6" | 200 lbs | - |
| Sanchez, Ernesto | 1B | Fort Wayne TinCaps | 23 | 08/02/2010 | Los Angeles | USA | Left | Left | 6' 2" | 190 lbs | - |
| Sanchez, Manny | CF | Lansing Lugnuts | 23 | 10/12/2010 | Salcedo | DOM | Right | Right | 6' 1" | 180 lbs | - |
| Sanchez, Willie | SP | Quad Cities River Bandits | 23 | 09/01/2010 | Bicknell | USA | Left | Left | 6' 6" | 200 lbs | - |
| Sanders, Jeremy | RF | Wisconsin Timber Rattlers | 28 | 01/28/2005 | Newport News | USA | Right | Right | 6' 1" | 195 lbs | - |
| Sandoval, Rodolfo | RP | Cedar Rapids Kernels | 27 | 12/01/2005 | Bajos de Haina | DOM | Right | Right | 6' 6" | 200 lbs | - |
| Santos, Alex | RP | Free Agent | 31 | 02/10/2002 | New York | USA | Right | Right | 6' 3" | 200 lbs | - |
| Santos, Gregory | RP | Fort Wayne TinCaps | 34 | 08/28/1999 | San Cristóbal | DOM | Right | Right | 6' 2" | 200 lbs | $1,600,000 |
| Schmidt, Steve | SP | Dayton Dragons | 28 | 10/12/2005 | Indianapolis | USA | Left | Left | 6' 0" | 200 lbs | - |
| Schmude, Kevin | SS | Fort Wayne TinCaps | 25 | 02/05/2008 | New York | USA | Right | Right | 6' 0" | 195 lbs | $810,000 |
| Sepulveda, Jose | 3B | Cedar Rapids Kernels | 28 | 03/25/2005 | Antriol | ANT | Right | Right | 6' 1" | 190 lbs | - |
| Sharp, Brad | SP | South Bend Cubs | 26 | 01/25/2007 | Nedrow | USA | Left | Left | 6' 1" | 195 lbs | - |
| Shepherd, Jim | 3B | Fort Wayne TinCaps | 24 | 12/19/2008 | Burke | USA | Right | Right | 6' 2" | 200 lbs | - |
| Sierra, Jorge | 2B | Dayton Dragons | 24 | 04/12/2009 | Santo Domingo | DOM | Right | Right | 5' 10" | 185 lbs | - |
| Simmons, Jerriel | 2B | Beloit Snappers | 22 | 02/09/2011 | San Clemente | USA | Left | Right | 5' 11" | 185 lbs | - |
| Sitch, Mike | SS | Fort Wayne TinCaps | 23 | 08/19/2010 | Ahoskie | USA | Switch | Right | 6' 4" | 205 lbs | - |
| Small, Dan | RP | West Michigan Whitecaps | 24 | 10/10/2009 | Conning Towers-Nautilus Park | USA | Right | Right | 6' 3" | 200 lbs | - |
| Smith, Jeremy | SP | Lansing Lugnuts | 23 | 01/11/2010 | Kingsford | USA | Switch | Right | 5' 10" | 175 lbs | - |
| Sotelo, Tony | RP | Wisconsin Timber Rattlers | 24 | 11/04/2009 | Santo Domingo | DOM | Left | Right | 5' 11" | 170 lbs | - |
| Soto, Jesus | RP | Lansing Lugnuts | 23 | 07/22/2010 | Santo Domingo | DOM | Left | Right | 5' 9" | 165 lbs | - |
| Soto, Mario | SS | Lake County Captains | 27 | 02/25/2006 | Jacksonville | USA | Left | Right | 6' 4" | 200 lbs | - |
| Stein, Chris | RP | Lansing Lugnuts | 24 | 09/04/2009 | Anchorage | USA | Right | Right | 6' 5" | 185 lbs | - |
| Stewart, Mike | C | Quad Cities River Bandits | 23 | 08/30/2010 | Gilbert | USA | Right | Right | 6' 7" | 200 lbs | - |
| Stokes, Jonathan | 3B | Lansing Lugnuts | 24 | 08/12/2009 | Victorville | USA | Right | Right | 6' 0" | 200 lbs | - |
| Stone, Billy | CF | Quad Cities River Bandits | 28 | 01/13/2005 | Highland | USA | Right | Right | 6' 1" | 200 lbs | - |
| Suarez, Edwin | RF | Lake County Captains | 28 | 06/03/2005 | Santo Domingo | DOM | Left | Left | 6' 2" | 200 lbs | - |
