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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | OAVG | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Cy Falkenberg | .1573 | 1909 | |
| 2 | Toros Inanc# | .1626 | 2062 | |
| 3 | Ferdie Schupp | .1636 | 1916 | |
| 4 | Pedro Martinez* | .1660 | 2000 | |
| 5 | Luis Tiant | .1678 | 1968 | |
| 6 | Nolan Ryan* | .1683 | 1991 | |
| 7 | Nolan Ryan* | .1689 | 1972 | |
| 8 | Ed Reulbach | .1711 | 1906 | |
| 9 | Tom Hall | .1718 | 1970 | |
| 10 | Matt Moore* | .1726 | 2014 | |
| 11 | Ramón Mercado | .1727 | 2024 | |
| 12 | Maurílio Mena | .1732 | 2039 | |
| 13 | Sandy Koufax* | .1775 | 1965 | |
| 13 | Willie Mitchell | .1775 | 1913 | |
| 15 | Hideo Nomo | .1784 | 1995 | |
| 16 | Dutch Leonard | .1787 | 1914 | |
| 17 | Tim Russell* | .1789 | 2029 | |
| 18 | Mao Qiao* | .1795 | 2029 | |
| 19 | Sid Fernandez | .1800 | 1985 | |
| 19 | Dave McNally | .1800 | 1968 | |
| 21 | Miroslav Teuner | .1811 | 2053 | |
| 22 | Tommy Byrne | .1817 | 1949 | |
| 23 | Al Downing | .1821 | 1963 | |
| 24 | Herb Score | .1822 | 1956 | |
| 25 | Bob Gibson* | .1823 | 1968 | |
| 26 | Pedro Martinez* | .1824 | 1997 | |
| 27 | Russ Ford | .1825 | 1910 | |
| 28 | Wynn Wilson | .1830 | 2058 | |
| 29 | Ed Walsh* | .1832 | 1910 | |
| 30 | Gustav Cada | .1833 | 2037 | |
| 30 | Sam McDowell | .1833 | 1965 | |
| 32 | Dick Radatz | .1836 | 1964 | |
| 33 | Georgy Vyazenkin | .1838 | 2056 | |
| 34 | Mao Qiao* | .1842 | 2032 | |
| 35 | Walter Johnson* | .1844 | 1913 | |
| 36 | Nolan Ryan* | .1845 | 1989 | |
| 37 | José Vélez# | .1846 | 2064 | |
| 38 | Mike Scott | .1848 | 1986 | |
| 39 | Mario Soto | .1850 | 1980 | |
| 39 | Nolan Ryan* | .1850 | 1981 | |
| 41 | Darwin Craig | .1853 | 2052 | |
| 42 | Carl Lundgren | .1854 | 1907 | |
| 43 | Pete Alexander* | .1859 | 1915 | |
| 44 | Floyd Youmans | .1861 | 1986 | |
| 45 | Earnest Dixon | .1862 | 2030 | |
| 46 | Nolan Ryan* | .1864 | 1990 | |
| 46 | Les Kempink* | .1864 | 2042 | |
| 48 | Nolan Ryan* | .1865 | 1986 | |
| 49 | Sam McDowell | .1868 | 1968 | |
| 49 | Joe Bowden | .1868 | 2018 | |
| 51 | Sam McDowell | .1871 | 1966 | |
| 51 | Ramón Mercado | .1871 | 2030 | |
| 51 | Catfish Hunter* | .1871 | 1972 | |
| 54 | Don Sutton* | .1873 | 1972 | |
| 55 | Sandy Koufax* | .1874 | 1963 | |
| 56 | Nolan Ryan* | .1876 | 1974 | |
| 57 | Tim Russell* | .1877 | 2030 | |
| 58 | Georgy Vyazenkin | .1879 | 2054 | |
| 58 | Vida Blue | .1879 | 1971 | |
| 60 | Nolan Ryan* | .1882 | 1977 | |
| 60 | Steven Morrison | .1882 | 2056 | |
| 62 | Mao Qiao* | .1883 | 2028 | |
| 63 | Sid Fernandez | .1884 | 1988 | |
| 64 | Chris R. Young | .1885 | 2007 | |
| 65 | Andy Messersmith | .1886 | 1969 | |
| 66 | Joe Horlen | .1888 | 1964 | |
| 66 | Alex Thompson | .1888 | 2051 | |
| 68 | Steve Genge* | .1893 | 2020 | |
| 69 | Ramón Mercado | .1894 | 2033 | |
| 69 | Bob Turley | .1894 | 1955 | |
| 71 | Sandy Koufax* | .1897 | 1964 | |
| 72 | Luis Jaramillo | .1898 | 2031 | |
| 73 | Mordecai Brown* | .1901 | 1908 | |
| 74 | Ron Guidry | .1902 | 1978 | |
| 75 | Guang Hor | .1904 | 2054 | |
| 75 | Joe Milton | .1904 | 2052 | |
| 77 | Joe Bowden | .1905 | 2019 | |
| 78 | Waylon Jamison | .1906 | 2052 | |
| 79 | Johan Santana | .1907 | 2004 | |
| 80 | Ken Walker | .1909 | 2058 | |
| 81 | Bob Turley | .1911 | 1957 | |
| 82 | Toros Inanc# | .1912 | 2061 | |
| 83 | Justin Verlander | .1914 | 2011 | |
| 83 | Addie Joss* | .1914 | 1908 | |
| 85 | Mao Qiao* | .1915 | 2031 | |
| 86 | Benjamin Tjelta | .1916 | 2040 | |
| 87 | Larry Cheney | .1918 | 1916 | |
| 87 | Nolan Ryan* | .1918 | 1976 | |
| 89 | Kiyonobu Nagai | .1921 | 2057 | |
| 90 | Herb Score | .1922 | 1955 | |
| 91 | Mark Eichhorn | .1923 | 1986 | |
| 91 | Joe Farr# | .1923 | 2058 | |
| 93 | Rube Waddell* | .1925 | 1905 | |
| 93 | Nolan Ryan* | .1925 | 1983 | |
| 95 | Fred Beebe | .1928 | 1908 | |
| 96 | Stan Coveleski* | .1929 | 1917 | |
| 97 | Ed Hickey | .1930 | 2030 | |
| 97 | Juan Berenguer | .1930 | 1983 | |
| 99 | Miroslav Teuner | .1931 | 2052 | |
| 100 | Randy Johnson* | .1932 | 1997 |
