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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | RBI | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Hack Wilson* | 191 | 1930 | |
| 2 | Lou Gehrig* | 184 | 1931 | |
| 3 | Garth Higgins* | 183 | 2050 | |
| 3 | Hank Greenberg* | 183 | 1937 | |
| 5 | Jimmie Foxx* | 175 | 1938 | |
| 5 | Lou Gehrig* | 175 | 1927 | |
| 7 | Lou Gehrig* | 174 | 1930 | |
| 8 | Mario Garza* | 173 | 2045 | |
| 9 | Garth Higgins* | 172 | 2047 | |
| 10 | Babe Ruth* | 171 | 1921 | |
| 11 | Hank Greenberg* | 170 | 1935 | |
| 11 | Chuck Klein* | 170 | 1930 | |
| 13 | Jimmie Foxx* | 169 | 1932 | |
| 13 | Mario Garza* | 169 | 2044 | |
| 15 | Joe DiMaggio* | 167 | 1937 | |
| 16 | Manny Ramirez* | 165 | 1999 | |
| 16 | Al Simmons* | 165 | 1930 | |
| 16 | Lou Gehrig* | 165 | 1934 | |
| 16 | Sam Thompson* | 165 | 1895 | |
| 20 | Babe Ruth* | 164 | 1927 | |
| 21 | Babe Ruth* | 163 | 1931 | |
| 21 | Jimmie Foxx* | 163 | 1933 | |
| 23 | Hal Trosky | 162 | 1936 | |
| 24 | Sammy Sosa | 160 | 2001 | |
| 24 | José López | 160 | 2023 | |
| 26 | Hack Wilson* | 159 | 1929 | |
| 26 | Lou Gehrig* | 159 | 1937 | |
| 26 | Vern Stephens | 159 | 1949 | |
| 26 | Ted Williams* | 159 | 1949 | |
| 30 | Sammy Sosa | 158 | 1998 | |
| 31 | Al Simmons* | 157 | 1929 | |
| 31 | Juan Gonzalez | 157 | 1998 | |
| 33 | Alex Rodriguez* | 156 | 2007 | |
| 33 | Tyler Dooley* | 156 | 2045 | |
| 33 | Tyler Dooley* | 156 | 2050 | |
| 33 | Brian Mustill* | 156 | 2049 | |
| 33 | Jimmie Foxx* | 156 | 1930 | |
| 38 | Brian Mustill* | 155 | 2046 | |
| 38 | Ken Williams | 155 | 1922 | |
| 38 | Cody Thomas | 155 | 2025 | |
| 38 | Joe DiMaggio* | 155 | 1948 | |
| 42 | Joe Medwick* | 154 | 1937 | |
| 42 | Babe Ruth* | 154 | 1929 | |
| 44 | Babe Ruth* | 153 | 1930 | |
| 44 | Tommy Davis | 153 | 1962 | |
| 46 | Lou Gehrig* | 152 | 1936 | |
| 46 | Albert Belle | 152 | 1998 | |
| 46 | Rogers Hornsby* | 152 | 1922 | |
| 46 | Brian Mustill* | 152 | 2044 | |
| 50 | Stanley Cunningham | 151 | 2047 | |
| 50 | Horst Kiefer | 151 | 2046 | |
| 50 | Mel Ott* | 151 | 1929 | |
| 50 | Al Simmons* | 151 | 1932 | |
| 50 | Lou Gehrig* | 151 | 1932 | |
| 55 | Rick Roberts | 150 | 2028 | |
| 55 | Andres Galarraga | 150 | 1996 | |
| 55 | Hank Greenberg* | 150 | 1940 | |
| 55 | Babe Ruth* | 150 | 1926 | |
| 55 | Miguel Tejada | 150 | 2004 | |
| 60 | George Foster | 149 | 1977 | |
| 60 | Ryan Howard | 149 | 2006 | |
| 60 | Rogers Hornsby* | 149 | 1929 | |
| 63 | David Ortiz | 148 | 2005 | |
| 63 | Johnny Bench* | 148 | 1970 | |
| 63 | Albert Belle | 148 | 1996 | |
| 63 | Xander Bogaerts* | 148 | 2023 | |
| 63 | Rafael Palmeiro | 148 | 1999 | |
| 63 | Horst Kiefer | 148 | 2044 | |
| 69 | Domingo Corona | 147 | 2047 | |
| 69 | Mark McGwire | 147 | 1998 | |
| 69 | Mark McGwire | 147 | 1999 | |
| 69 | Tyler Tewell* | 147 | 2019 | |
| 69 | Kyoichi Fukuda* | 147 | 2045 | |
| 69 | Todd Helton* | 147 | 2000 | |
| 69 | Ken Griffey Jr.* | 147 | 1997 | |
| 69 | Cap Anson* | 147 | 1886 | |
| 77 | Ryan Howard | 146 | 2008 | |
| 77 | Valerio Restolho | 146 | 2035 | |
| 77 | Jarrod Dixon | 146 | 2038 | |
| 77 | Ken Griffey Jr.* | 146 | 1998 | |
| 77 | Ryunosuke Okuta | 146 | 2034 | |
| 77 | Horst Kiefer | 146 | 2047 | |
| 77 | Hank Greenberg* | 146 | 1938 | |
| 77 | Todd Helton* | 146 | 2001 | |
| 77 | Ed Delahanty* | 146 | 1893 | |
| 86 | Don Mattingly | 145 | 1985 | |
| 86 | Al Rosen | 145 | 1953 | |
| 86 | Manny Ramirez* | 145 | 1998 | |
| 86 | Ted Williams* | 145 | 1939 | |
| 86 | Hugh Duffy* | 145 | 1894 | |
| 86 | Carlos Delgado | 145 | 2003 | |
| 86 | Edgar Martinez | 145 | 2000 | |
| 86 | Chuck Klein* | 145 | 1929 | |
| 94 | Walt Dropo | 144 | 1950 | |
| 94 | Vern Stephens | 144 | 1950 | |
| 94 | Manny Ramirez* | 144 | 2005 | |
| 94 | Mark Teixeira | 144 | 2005 | |
| 94 | Xander Bogaerts* | 144 | 2019 | |
| 94 | Mike Sweeney | 144 | 2000 | |
| 94 | Juan Gonzalez | 144 | 1996 |
