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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K9 | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Craig Kimbrel* | 13.05 | 2010-2026 | |
| 2 | Rex Brothers | 12.94 | 2011-2027 | |
| 3 | Aroldis Chapman* | 12.47 | 2010-2025 | |
| 4 | Jonathan Broxton | 11.97 | 2005-2023 | |
| 5 | Jared Mann | 11.44 | 2022-2038 | |
| 6 | Guang Hor | 11.35 | 2050-2063 | |
| 7 | Octavio Dotel | 11.02 | 1999-2015 | |
| 8 | Miroslav Teuner | 10.97 | 2051-2064 | |
| 9 | Viktor Johansson | 10.88 | 2055-2064 | |
| 10 | Toros Inanc# | 10.76 | 2057-2067 | |
| 10 | Juan Guillén | 10.76 | 2045-2062 | |
| 12 | Connor Garner* | 10.74 | 2024-2037 | |
| 13 | Waylon Jamison | 10.72 | 2047-2065 | |
| 14 | Mao Qiao* | 10.67 | 2025-2039 | |
| 14 | Dan Madison | 10.67 | 2049-2064 | |
| 16 | Matt Hutchings | 10.65 | 2050-2063 | |
| 17 | Randy Johnson* | 10.61 | 1988-2009 | |
| 18 | Ramón Mercado | 10.50 | 2021-2036 | |
| 19 | Kerry Wood | 10.32 | 1998-2012 | |
| 20 | Pat Taylor# | 10.25 | 2053-2067 | |
| 21 | Huston Street | 10.23 | 2005-2021 | |
| 22 | Ken Smith | 10.20 | 2023-2037 | |
| 23 | Josh Edgin | 10.13 | 2012-2027 | |
| 24 | Matt Moore* | 10.06 | 2011-2027 | |
| 25 | Pedro Martinez* | 10.04 | 1992-2009 | |
| 26 | J.P. Howell | 9.99 | 2005-2024 | |
| 27 | Jouko Sulkunen | 9.94 | 2048-2058 | |
| 28 | Matt Harvey | 9.87 | 2012-2023 | |
| 29 | Drew Storen | 9.83 | 2010-2027 | |
| 30 | Joe Hendrickson | 9.74 | 2042-2058 | |
| 31 | Blake Parker | 9.68 | 2012-2025 | |
| 32 | Steven Morrison | 9.66 | 2053-2063 | |
| 33 | Wynn Wilson | 9.64 | 2053-2062 | |
| 34 | Nestor Uspensky# | 9.57 | 2060-2067 | |
| 35 | Nolan Ryan* | 9.55 | 1966-1993 | |
| 36 | Michel Rossignol | 9.53 | 2043-2054 | |
| 37 | Yoichibei Hoshino# | 9.51 | 2059-2066 | |
| 38 | Yu Darvish | 9.42 | 2012-2024 | |
| 39 | Jov Zhmuro# | 9.40 | 2057-2067 | |
| 40 | Tim Lincecum* | 9.38 | 2007-2023 | |
| 40 | Tom Gaines | 9.38 | 2035-2047 | |
| 42 | Ken Bishop# | 9.37 | 2060-2067 | |
| 43 | Trevor Hoffman* | 9.36 | 1993-2010 | |
| 44 | Rory Adamczak# | 9.34 | 2054-2067 | |
| 45 | Neftali Feliz | 9.33 | 2009-2022 | |
| 46 | Danny O'connell# | 9.29 | 2056-2067 | |
| 47 | Sandy Koufax* | 9.28 | 1955-1966 | |
| 48 | Christophe Roy | 9.27 | 2048-2064 | |
| 49 | Gerrit Cole | 9.25 | 2014-2024 | |
| 50 | Yimi Garcia | 9.23 | 2015-2029 | |
| 51 | Steve Genge* | 9.22 | 2019-2030 | |
| 52 | Vladmir Paidoverov | 9.20 | 2044-2053 | |
| 53 | Pedro Hernández* | 9.19 | 2031-2045 | |
| 54 | Dermott Sheen | 9.18 | 2049-2059 | |
| 55 | Trevor Bauer | 9.15 | 2012-2025 | |
| 55 | Juan Medina | 9.15 | 2019-2031 | |
| 57 | José Carrillo | 9.14 | 2016-2029 | |
| 58 | Oliver Perez | 9.13 | 2002-2018 | |
| 59 | Georgy Vyazenkin | 9.10 | 2051-2059 | |
| 60 | Yovani Gallardo | 9.09 | 2007-2017 | |
| 60 | Gustav Cada | 9.09 | 2034-2045 | |
| 60 | Xavier García | 9.09 | 2030-2040 | |
| 63 | José Vélez# | 9.05 | 2060-2067 | |
| 64 | Paco Miller | 9.03 | 2020-2034 | |
| 65 | Maurílio Mena | 9.00 | 2034-2050 | |
| 66 | César Nava* | 8.98 | 2030-2049 | |
| 67 | T.J. Walz | 8.96 | 2017-2030 | |
| 68 | Goro Kichida | 8.94 | 2039-2049 | |
| 69 | César Jiménez# | 8.91 | 2059-2067 | |
| 69 | Stephen Strasburg* | 8.91 | 2010-2029 | |
| 71 | Chris Sale | 8.90 | 2010-2028 | |
| 72 | Nathan Baker | 8.89 | 2017-2029 | |
| 72 | Tim Russell* | 8.89 | 2022-2035 | |
| 72 | Zack Wheeler | 8.89 | 2013-2028 | |
| 75 | Kyle Wilkins | 8.86 | 2020-2035 | |
| 75 | Sam McDowell | 8.86 | 1961-1975 | |
| 77 | Sulevi Tiilikainen | 8.85 | 2051-2066 | |
| 78 | Brayan Villarreal | 8.84 | 2011-2019 | |
| 78 | Larry MacIntyre# | 8.84 | 2060-2067 | |
| 80 | Bert Collins# | 8.83 | 2057-2067 | |
| 81 | Yoely Bello | 8.81 | 2015-2028 | |
| 82 | Fabian Santana | 8.80 | 2054-2065 | |
| 82 | Johan Santana | 8.80 | 2000-2014 | |
| 84 | Andrés Hidalgo | 8.79 | 2022-2032 | |
| 85 | Alex Thompson | 8.78 | 2049-2058 | |
| 86 | Bob Henderson | 8.77 | 2045-2060 | |
| 87 | Francisco Liriano | 8.76 | 2005-2016 | |
| 88 | Dan Plesac | 8.74 | 1986-2003 | |
| 89 | Hideo Nomo | 8.73 | 1995-2008 | |
| 89 | Lee Smith | 8.73 | 1980-1997 | |
| 89 | Arthur Rhodes | 8.73 | 1991-2011 | |
| 89 | Clayton Kershaw | 8.73 | 2008-2025 | |
| 93 | José Guerrero | 8.72 | 2028-2044 | |
| 93 | Alberto Lara | 8.72 | 2024-2035 | |
| 95 | Brandon Morrow | 8.71 | 2007-2019 | |
| 95 | Harvey May# | 8.71 | 2053-2067 | |
| 95 | Héctor López | 8.71 | 2058-2064 | |
| 98 | Bubba Myers | 8.69 | 2041-2051 | |
| 98 | Steve Williams | 8.69 | 2036-2046 | |
| 100 | Jeurys Familia | 8.68 | 2012-2024 |
