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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | BB | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Nolan Ryan* | 2795 | 1966-1993 | |
| 2 | Steve Carlton* | 1833 | 1965-1988 | |
| 3 | Phil Niekro* | 1809 | 1964-1987 | |
| 4 | Early Wynn* | 1775 | 1939-1963 | |
| 5 | Bob Feller* | 1764 | 1936-1956 | |
| 6 | Bobo Newsom | 1732 | 1929-1953 | |
| 7 | Charlie Hough | 1665 | 1970-1994 | |
| 8 | Amos Rusie* | 1588 | 1890-1901 | |
| 9 | Roger Clemens | 1580 | 1984-2007 | |
| 10 | Red Ruffing* | 1541 | 1924-1947 | |
| 11 | Tom Glavine* | 1500 | 1987-2008 | |
| 12 | Randy Johnson* | 1497 | 1988-2009 | |
| 13 | Bump Hadley | 1442 | 1926-1941 | |
| 14 | César Nava* | 1434 | 2030-2049 | |
| 14 | Warren Spahn* | 1434 | 1942-1965 | |
| 16 | Earl Whitehill | 1431 | 1923-1939 | |
| 17 | Sam Jones | 1396 | 1914-1935 | |
| 18 | Jack Morris | 1390 | 1977-1994 | |
| 18 | Tom Seaver* | 1390 | 1967-1986 | |
| 20 | Gaylord Perry* | 1379 | 1962-1983 | |
| 21 | Bobby Witt | 1375 | 1986-2001 | |
| 22 | Mike Torrez | 1371 | 1967-1984 | |
| 23 | Walter Johnson* | 1363 | 1907-1927 | |
| 24 | Don Sutton* | 1343 | 1966-1988 | |
| 25 | Bob Gibson* | 1336 | 1959-1975 | |
| 26 | Chuck Finley | 1332 | 1986-2002 | |
| 27 | Bert Blyleven* | 1322 | 1970-1992 | |
| 28 | Sam McDowell | 1312 | 1961-1975 | |
| 29 | Jim Palmer* | 1311 | 1965-1984 | |
| 30 | Tim Lincecum* | 1307 | 2007-2023 | |
| 31 | Burleigh Grimes* | 1295 | 1916-1934 | |
| 32 | Mark Langston | 1289 | 1984-1999 | |
| 33 | Kid Nichols* | 1268 | 1890-1906 | |
| 34 | Joe Bush | 1263 | 1912-1928 | |
| 35 | Joe Niekro | 1262 | 1967-1988 | |
| 36 | Allie Reynolds | 1261 | 1942-1954 | |
| 37 | Tommy John | 1259 | 1963-1989 | |
| 38 | Frank Tanana | 1255 | 1973-1993 | |
| 39 | Bob Lemon* | 1251 | 1941-1958 | |
| 40 | Hal Newhouser* | 1249 | 1939-1955 | |
| 41 | Ryan Dempster | 1213 | 1998-2015 | |
| 41 | Red Faber* | 1213 | 1914-1933 | |
| 43 | Vic Willis* | 1212 | 1898-1910 | |
| 44 | Tim Wakefield | 1205 | 1992-2011 | |
| 45 | Brickyard Kennedy | 1201 | 1892-1903 | |
| 46 | Jerry Koosman | 1198 | 1967-1985 | |
| 47 | Tommy Bridges | 1192 | 1930-1946 | |
| 48 | Ted Breitenstein | 1189 | 1892-1901 | |
| 49 | Lefty Grove* | 1187 | 1925-1941 | |
| 50 | Vida Blue | 1185 | 1969-1986 | |
| 51 | Zack Wheeler | 1179 | 2013-2028 | |
| 52 | Billy Pierce | 1178 | 1945-1964 | |
| 53 | Kenny Rogers | 1175 | 1989-2008 | |
| 54 | Dennis Martinez | 1165 | 1976-1998 | |
| 55 | Al Leiter | 1163 | 1987-2005 | |
| 56 | Mike Moore | 1156 | 1982-1995 | |
| 57 | Jamie Moyer | 1155 | 1986-2012 | |
| 58 | Fernando Valenzuela | 1151 | 1980-1997 | |
| 59 | David Cone | 1137 | 1986-2003 | |
| 60 | Carlos Zambrano | 1134 | 2001-2016 | |
| 61 | Johnny Vander Meer | 1132 | 1937-1951 | |
| 62 | Bill Hutchison | 1131 | 1889-1897 | |
| 62 | George Mullin | 1131 | 1902-1913 | |
| 64 | Jerry Reuss | 1127 | 1969-1990 | |
| 65 | Ted Lyons* | 1121 | 1923-1946 | |
| 65 | Bucky Walters | 1121 | 1931-1950 | |
| 67 | Barry Zito | 1119 | 2000-2016 | |
| 68 | Mel Harder | 1118 | 1928-1947 | |
| 69 | Bob Buhl | 1105 | 1953-1967 | |
| 70 | Luis Tiant | 1104 | 1964-1982 | |
| 71 | Mickey Lolich | 1099 | 1963-1979 | |
| 72 | Nathan Baker | 1097 | 2017-2029 | |
| 73 | Lefty Gomez* | 1095 | 1930-1943 | |
| 74 | Matt Cain | 1094 | 2005-2025 | |
| 75 | Virgil Trucks | 1088 | 1941-1958 | |
| 76 | Whitey Ford* | 1086 | 1950-1967 | |
| 77 | Jim Kaat | 1083 | 1959-1983 | |
| 78 | Eppa Rixey* | 1082 | 1912-1933 | |
| 79 | Rick Sutcliffe | 1081 | 1976-1994 | |
| 80 | Mickey Welch* | 1077 | 1883-1892 | |
| 81 | Camilo Pascual | 1069 | 1954-1971 | |
| 82 | Bob Turley | 1068 | 1951-1963 | |
| 83 | Hooks Dauss | 1067 | 1912-1926 | |
| 83 | Livan Hernandez | 1067 | 1996-2013 | |
| 85 | Alfonso Sánchez | 1065 | 2018-2035 | |
| 86 | Joe Hendrickson | 1064 | 2042-2058 | |
| 87 | Curt Simmons | 1063 | 1947-1967 | |
| 88 | Murry Dickson | 1058 | 1939-1959 | |
| 89 | Vern Kennedy | 1049 | 1934-1945 | |
| 89 | Andy Pettitte | 1049 | 1995-2014 | |
| 91 | Dizzy Trout | 1046 | 1939-1957 | |
| 92 | Wes Ferrell | 1040 | 1927-1941 | |
| 93 | Tommy Byrne | 1037 | 1943-1957 | |
| 94 | Red Ames | 1034 | 1903-1919 | |
| 94 | Yu Darvish | 1034 | 2012-2024 | |
| 94 | Dave Stewart | 1034 | 1978-1995 | |
| 94 | Dave Stieb | 1034 | 1979-1998 | |
| 94 | Bob Welch | 1034 | 1978-1994 | |
| 99 | Rube Walberg | 1031 | 1923-1937 | |
| 100 | Gio Gonzalez | 1027 | 2008-2023 |
