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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Nolan Ryan* | 5714 | 1966-1993 | |
| 2 | Randy Johnson* | 4875 | 1988-2009 | |
| 3 | Roger Clemens | 4672 | 1984-2007 | |
| 4 | Steve Carlton* | 4136 | 1965-1988 | |
| 5 | Bert Blyleven* | 3701 | 1970-1992 | |
| 6 | César Nava* | 3641 | 2030-2049 | |
| 7 | Tom Seaver* | 3640 | 1967-1986 | |
| 8 | Don Sutton* | 3574 | 1966-1988 | |
| 9 | Gaylord Perry* | 3534 | 1962-1983 | |
| 10 | Walter Johnson* | 3509 | 1907-1927 | |
| 11 | Tim Lincecum* | 3440 | 2007-2023 | |
| 12 | Greg Maddux* | 3371 | 1986-2008 | |
| 13 | Phil Niekro* | 3342 | 1964-1987 | |
| 14 | Mao Qiao* | 3319 | 2025-2039 | |
| 15 | Rubén Marrero* | 3305 | 2023-2038 | |
| 16 | Zack Greinke | 3223 | 2004-2027 | |
| 17 | Fergie Jenkins* | 3192 | 1965-1983 | |
| 18 | Clayton Kershaw | 3190 | 2008-2025 | |
| 19 | Pedro Martinez* | 3154 | 1992-2009 | |
| 20 | Bob Gibson* | 3117 | 1959-1975 | |
| 21 | Curt Schilling | 3116 | 1988-2007 | |
| 22 | John Smoltz* | 3084 | 1988-2009 | |
| 23 | Stephen Strasburg* | 3083 | 2010-2029 | |
| 24 | Zack Wheeler | 3071 | 2013-2028 | |
| 25 | Anthony Osborn* | 3056 | 2034-2048 | |
| 26 | Matt Moore* | 2985 | 2011-2027 | |
| 27 | Herkko Kangas | 2956 | 2049-2066 | |
| 28 | Shelby Miller | 2909 | 2012-2029 | |
| 29 | Jim Bunning* | 2855 | 1955-1971 | |
| 30 | Mickey Lolich | 2832 | 1963-1979 | |
| 31 | Mike Mussina* | 2813 | 1991-2008 | |
| 32 | Connor Garner* | 2806 | 2024-2037 | |
| 33 | Frank Tanana | 2773 | 1973-1993 | |
| 34 | Matt Cain | 2755 | 2005-2025 | |
| 35 | Ramón Mercado | 2737 | 2021-2036 | |
| 36 | Felix Hernandez* | 2717 | 2005-2021 | |
| 37 | Sergio Martínez | 2672 | 2018-2033 | |
| 38 | David Cone | 2668 | 1986-2003 | |
| 39 | Josh Goode | 2655 | 2047-2061 | |
| 40 | Justin Verlander | 2654 | 2005-2019 | |
| 41 | CC Sabathia | 2632 | 2001-2016 | |
| 42 | Mark Andelbeek* | 2611 | 2034-2052 | |
| 43 | Chuck Finley | 2610 | 1986-2002 | |
| 44 | Tom Glavine* | 2607 | 1987-2008 | |
| 45 | Danny Salazar | 2602 | 2014-2033 | |
| 46 | Joe Hendrickson | 2584 | 2042-2058 | |
| 47 | Warren Spahn* | 2583 | 1942-1965 | |
| 48 | Bob Feller* | 2581 | 1936-1956 | |
| 49 | Alfonso Sánchez | 2580 | 2018-2035 | |
| 50 | Mike Minor | 2574 | 2010-2030 | |
| 51 | Bob Henderson | 2559 | 2045-2060 | |
| 52 | Jerry Koosman | 2556 | 1967-1985 | |
| 53 | Javier Vazquez | 2536 | 1998-2011 | |
| 54 | Chris Sale | 2535 | 2010-2028 | |
| 55 | William Callahan | 2526 | 2045-2059 | |
| 56 | Fred Morrow | 2516 | 2018-2035 | |
| 57 | Christy Mathewson* | 2502 | 1900-1916 | |
| 58 | Maurílio Mena | 2487 | 2034-2050 | |
| 59 | Don Drysdale* | 2486 | 1956-1969 | |
| 60 | Jack Morris | 2478 | 1977-1994 | |
| 61 | Erik Stover | 2476 | 2042-2061 | |
| 62 | Mark Langston | 2464 | 1984-1999 | |
| 63 | Jim Kaat | 2461 | 1959-1983 | |
| 64 | Sam McDowell | 2453 | 1961-1975 | |
| 65 | Ed Hickey | 2447 | 2020-2036 | |
| 66 | Jamie Moyer | 2441 | 1986-2012 | |
| 67 | Luis Tiant | 2416 | 1964-1982 | |
| 68 | Roy Halladay* | 2414 | 1998-2015 | |
| 68 | Andy Pettitte | 2414 | 1995-2014 | |
| 70 | Darwin Craig | 2407 | 2047-2062 | |
| 71 | Guang Hor | 2406 | 2050-2063 | |
| 72 | Dennis Eckersley* | 2401 | 1975-1998 | |
| 73 | Kevin Brown | 2397 | 1986-2005 | |
| 74 | Sandy Koufax* | 2396 | 1955-1966 | |
| 75 | Pedro Hernández* | 2393 | 2031-2045 | |
| 75 | Jonathon Niese | 2393 | 2008-2025 | |
| 77 | Tim Russell* | 2379 | 2022-2035 | |
| 78 | Charlie Hough | 2362 | 1970-1994 | |
| 79 | Harvey May# | 2359 | 2053-2067 | |
| 79 | Tyler Skaggs | 2359 | 2012-2030 | |
| 81 | Robin Roberts* | 2357 | 1948-1966 | |
| 82 | Ryan Dempster | 2346 | 1998-2015 | |
| 83 | Bill Taylor# | 2342 | 2052-2067 | |
| 84 | José Hernández | 2340 | 2039-2054 | |
| 85 | Early Wynn* | 2334 | 1939-1963 | |
| 86 | Toros Inanc# | 2319 | 2057-2067 | |
| 87 | Billy Kwachum | 2313 | 2034-2048 | |
| 88 | Juan Marichal* | 2303 | 1960-1975 | |
| 89 | Dwight Gooden | 2293 | 1984-2000 | |
| 90 | Chris Richardson# | 2281 | 2053-2067 | |
| 91 | Chad Billingsley | 2271 | 2006-2022 | |
| 92 | Rube Waddell* | 2267 | 1900-1910 | |
| 93 | Lefty Grove* | 2266 | 1925-1941 | |
| 94 | Arhippa Raevuori | 2257 | 2030-2045 | |
| 95 | Tommy John | 2245 | 1963-1989 | |
| 96 | Randall Delgado | 2227 | 2011-2027 | |
| 97 | Jim Palmer* | 2212 | 1965-1984 | |
| 98 | A.J. Burnett | 2208 | 1999-2015 | |
| 99 | David Wells | 2201 | 1987-2007 | |
| 100 | Pete Alexander* | 2198 | 1911-1930 |
