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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | IP | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Walter Johnson* | 5914.0 | 1907-1927 | |
| 2 | Phil Niekro* | 5404.0 | 1964-1987 | |
| 3 | Nolan Ryan* | 5386.0 | 1966-1993 | |
| 4 | Gaylord Perry* | 5350.0 | 1962-1983 | |
| 5 | Don Sutton* | 5282.0 | 1966-1988 | |
| 6 | Warren Spahn* | 5243.0 | 1942-1965 | |
| 7 | Steve Carlton* | 5217.0 | 1965-1988 | |
| 8 | Pete Alexander* | 5190.0 | 1911-1930 | |
| 9 | Kid Nichols* | 5056.0 | 1890-1906 | |
| 10 | Greg Maddux* | 5008.0 | 1986-2008 | |
| 11 | Bert Blyleven* | 4970.0 | 1970-1992 | |
| 12 | Roger Clemens | 4916.0 | 1984-2007 | |
| 13 | Tom Seaver* | 4782.0 | 1967-1986 | |
| 14 | Christy Mathewson* | 4780.0 | 1900-1916 | |
| 15 | Tommy John | 4710.0 | 1963-1989 | |
| 16 | Robin Roberts* | 4688.0 | 1948-1966 | |
| 17 | Early Wynn* | 4564.0 | 1939-1963 | |
| 18 | Jim Kaat | 4530.0 | 1959-1983 | |
| 19 | Fergie Jenkins* | 4500.0 | 1965-1983 | |
| 20 | Eppa Rixey* | 4494.0 | 1912-1933 | |
| 21 | Tom Glavine* | 4413.0 | 1987-2008 | |
| 22 | Red Ruffing* | 4344.0 | 1924-1947 | |
| 23 | Eddie Plank* | 4227.0 | 1901-1917 | |
| 24 | Frank Tanana | 4188.0 | 1973-1993 | |
| 25 | Burleigh Grimes* | 4180.0 | 1916-1934 | |
| 26 | Ted Lyons* | 4161.0 | 1923-1946 | |
| 27 | Randy Johnson* | 4135.0 | 1988-2009 | |
| 28 | Red Faber* | 4086.0 | 1914-1933 | |
| 29 | Jamie Moyer | 4074.0 | 1986-2012 | |
| 30 | Cy Young* | 4003.0 | 1899-1911 | |
| 31 | Dennis Martinez | 3999.0 | 1976-1998 | |
| 32 | Vic Willis* | 3996.0 | 1898-1910 | |
| 33 | Jim Palmer* | 3948.0 | 1965-1984 | |
| 34 | Lefty Grove* | 3940.0 | 1925-1941 | |
| 35 | Zack Greinke | 3893.0 | 2004-2027 | |
| 36 | Bob Gibson* | 3884.0 | 1959-1975 | |
| 37 | Sam Jones | 3883.0 | 1914-1935 | |
| 38 | Jerry Koosman | 3839.0 | 1967-1985 | |
| 39 | Bob Feller* | 3827.0 | 1936-1956 | |
| 40 | Jack Morris | 3824.0 | 1977-1994 | |
| 41 | John Clarkson* | 3823.0 | 1884-1892 | |
| 42 | Jack Powell | 3822.0 | 1899-1912 | |
| 43 | Charlie Hough | 3801.0 | 1970-1994 | |
| 44 | Waite Hoyt* | 3762.0 | 1918-1938 | |
| 45 | Jim Bunning* | 3760.0 | 1955-1971 | |
| 46 | Bobo Newsom | 3759.0 | 1929-1953 | |
| 47 | Erik Stover | 3735.0 | 2042-2061 | |
| 48 | Jerry Reuss | 3669.0 | 1969-1990 | |
| 49 | Matt Cain | 3664.0 | 2005-2025 | |
| 50 | César Nava* | 3650.0 | 2030-2049 | |
| 51 | Bill Taylor# | 3647.0 | 2052-2072 | |
| 52 | Paul Derringer | 3645.0 | 1931-1945 | |
| 53 | Mickey Lolich | 3638.0 | 1963-1979 | |
| 54 | Bob Friend | 3611.0 | 1951-1966 | |
| 55 | Herkko Kangas | 3594.0 | 2049-2066 | |
| 56 | Carl Hubbell* | 3590.0 | 1928-1943 | |
| 57 | Joe Niekro | 3584.0 | 1967-1988 | |
| 58 | Mickey Welch* | 3579.0 | 1883-1892 | |
| 59 | Herb Pennock* | 3571.0 | 1912-1934 | |
| 60 | Earl Whitehill | 3564.0 | 1923-1939 | |
| 61 | Mike Mussina* | 3562.0 | 1991-2008 | |
| 62 | Rick Reuschel | 3548.0 | 1972-1991 | |
| 63 | Amos Rusie* | 3544.0 | 1890-1901 | |
| 64 | Juan Marichal* | 3507.0 | 1960-1975 | |
| 65 | Rubén Marrero* | 3489.0 | 2023-2038 | |
| 66 | Luis Tiant | 3486.0 | 1964-1982 | |
| 67 | Wilbur Cooper | 3480.0 | 1912-1926 | |
| 68 | John Smoltz* | 3473.0 | 1988-2009 | |
| 69 | Claude Osteen | 3460.0 | 1957-1975 | |
| 70 | George Mullin | 3451.0 | 1902-1913 | |
| 71 | Catfish Hunter* | 3449.0 | 1965-1979 | |
| 72 | David Wells | 3439.0 | 1987-2007 | |
| 73 | Don Drysdale* | 3432.0 | 1956-1969 | |
| 74 | Mel Harder | 3426.0 | 1928-1947 | |
| 75 | Mike Minor | 3401.0 | 2010-2030 | |
| 76 | Hooks Dauss | 3390.0 | 1912-1926 | |
| 77 | Doyle Alexander | 3367.0 | 1971-1989 | |
| 78 | Al Orth | 3354.0 | 1895-1909 | |
| 79 | Curt Simmons | 3348.0 | 1947-1967 | |
| 80 | Vida Blue | 3343.0 | 1969-1986 | |
| 81 | Alfonso Sánchez | 3326.0 | 2018-2035 | |
| 82 | Rube Marquard* | 3306.0 | 1908-1925 | |
| 82 | Billy Pierce | 3306.0 | 1945-1964 | |
| 84 | Jack Quinn | 3304.0 | 1909-1933 | |
| 85 | Kenny Rogers | 3302.0 | 1989-2008 | |
| 86 | Tim Lincecum* | 3300.0 | 2007-2023 | |
| 87 | Clayton Kershaw | 3289.0 | 2008-2025 | |
| 88 | Dennis Eckersley* | 3285.0 | 1975-1998 | |
| 88 | Jim Perry | 3285.0 | 1959-1975 | |
| 90 | Andy Pettitte | 3274.0 | 1995-2014 | |
| 91 | Larry Jackson | 3262.0 | 1955-1968 | |
| 92 | Curt Schilling | 3261.0 | 1988-2007 | |
| 93 | Kevin Brown | 3256.0 | 1986-2005 | |
| 94 | Anthony Osborn* | 3240.0 | 2034-2048 | |
| 95 | Tim Wakefield | 3226.0 | 1992-2011 | |
| 96 | Freddie Fitzsimmons | 3223.0 | 1925-1943 | |
| 96 | Eddie Cicotte | 3223.0 | 1905-1920 | |
| 98 | Dolf Luque | 3220.0 | 1914-1935 | |
| 99 | Mark Andelbeek* | 3219.0 | 2034-2052 | |
| 100 | Dutch Leonard | 3218.0 | 1933-1953 |
