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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | GS | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Nolan Ryan* | 773 | 1966-1993 | |
| 2 | Don Sutton* | 756 | 1966-1988 | |
| 3 | Greg Maddux* | 740 | 1986-2008 | |
| 4 | Phil Niekro* | 716 | 1964-1987 | |
| 5 | Steve Carlton* | 709 | 1965-1988 | |
| 6 | Roger Clemens | 707 | 1984-2007 | |
| 7 | Tommy John | 700 | 1963-1989 | |
| 8 | Gaylord Perry* | 690 | 1962-1983 | |
| 9 | Bert Blyleven* | 685 | 1970-1992 | |
| 10 | Tom Glavine* | 682 | 1987-2008 | |
| 11 | Walter Johnson* | 666 | 1907-1927 | |
| 12 | Warren Spahn* | 665 | 1942-1965 | |
| 13 | Tom Seaver* | 647 | 1967-1986 | |
| 14 | Jamie Moyer | 638 | 1986-2012 | |
| 15 | Jim Kaat | 625 | 1959-1983 | |
| 16 | Frank Tanana | 616 | 1973-1993 | |
| 17 | Early Wynn* | 612 | 1939-1963 | |
| 18 | Robin Roberts* | 609 | 1948-1966 | |
| 19 | Zack Greinke | 607 | 2004-2027 | |
| 20 | Randy Johnson* | 603 | 1988-2009 | |
| 21 | Pete Alexander* | 599 | 1911-1930 | |
| 22 | Fergie Jenkins* | 594 | 1965-1983 | |
| 23 | Erik Stover | 576 | 2042-2061 | |
| 24 | Dennis Martinez | 562 | 1976-1998 | |
| 25 | Kid Nichols* | 561 | 1890-1906 | |
| 26 | Matt Cain | 560 | 2005-2025 | |
| 27 | Eppa Rixey* | 552 | 1912-1933 | |
| 28 | Christy Mathewson* | 551 | 1900-1916 | |
| 29 | Jerry Reuss | 547 | 1969-1990 | |
| 30 | Alfonso Sánchez | 541 | 2018-2035 | |
| 31 | Mike Mussina* | 536 | 1991-2008 | |
| 31 | Red Ruffing* | 536 | 1924-1947 | |
| 33 | Mike Minor | 535 | 2010-2030 | |
| 34 | César Nava* | 531 | 2030-2049 | |
| 35 | Rick Reuschel | 529 | 1972-1991 | |
| 36 | Jerry Koosman | 527 | 1967-1985 | |
| 36 | Jack Morris | 527 | 1977-1994 | |
| 38 | Jim Palmer* | 521 | 1965-1984 | |
| 39 | Jim Bunning* | 519 | 1955-1971 | |
| 40 | Tim Lincecum* | 517 | 2007-2023 | |
| 41 | Ed Hickey | 511 | 2020-2036 | |
| 41 | Herkko Kangas | 511 | 2049-2066 | |
| 43 | Bill Taylor# | 510 | 2052-2067 | |
| 44 | Clayton Kershaw | 506 | 2008-2025 | |
| 44 | Andy Pettitte | 506 | 1995-2014 | |
| 46 | Shelby Miller | 500 | 2012-2029 | |
| 46 | Joe Niekro | 500 | 1967-1988 | |
| 48 | Eddie Plank* | 498 | 1901-1917 | |
| 49 | Bob Friend | 497 | 1951-1966 | |
| 49 | Burleigh Grimes* | 497 | 1916-1934 | |
| 51 | Mickey Lolich | 496 | 1963-1979 | |
| 52 | Zack Wheeler | 494 | 2013-2028 | |
| 53 | Mark Andelbeek* | 493 | 2034-2052 | |
| 54 | Sergio Martínez | 490 | 2018-2033 | |
| 55 | Rubén Marrero* | 489 | 2023-2038 | |
| 55 | David Wells | 489 | 1987-2007 | |
| 57 | Claude Osteen | 488 | 1957-1975 | |
| 58 | Sam Jones | 487 | 1914-1935 | |
| 59 | Bob Feller* | 484 | 1936-1956 | |
| 59 | Ted Lyons* | 484 | 1923-1946 | |
| 59 | Stephen Strasburg* | 484 | 2010-2029 | |
| 59 | Luis Tiant | 484 | 1964-1982 | |
| 63 | Red Faber* | 483 | 1914-1933 | |
| 63 | Bobo Newsom | 483 | 1929-1953 | |
| 65 | Bob Gibson* | 482 | 1959-1975 | |
| 66 | John Smoltz* | 481 | 1988-2009 | |
| 67 | Kevin Brown | 476 | 1986-2005 | |
| 67 | Catfish Hunter* | 476 | 1965-1979 | |
| 69 | Livan Hernandez | 474 | 1996-2013 | |
| 69 | Kenny Rogers | 474 | 1989-2008 | |
| 71 | Vida Blue | 473 | 1969-1986 | |
| 71 | Earl Whitehill | 473 | 1923-1939 | |
| 73 | Vic Willis* | 471 | 1898-1910 | |
| 74 | Josh Goode | 469 | 2047-2061 | |
| 74 | Jonathon Niese | 469 | 2008-2025 | |
| 76 | Chuck Finley | 467 | 1986-2002 | |
| 77 | Orel Hershiser | 466 | 1983-2000 | |
| 78 | Don Drysdale* | 465 | 1956-1969 | |
| 78 | Milt Pappas | 465 | 1957-1973 | |
| 80 | Doyle Alexander | 464 | 1971-1989 | |
| 81 | Tim Wakefield | 463 | 1992-2011 | |
| 82 | Curt Simmons | 462 | 1947-1967 | |
| 82 | Bob Welch | 462 | 1978-1994 | |
| 84 | Anthony Osborn* | 461 | 2034-2048 | |
| 85 | Salvador Negreta | 460 | 2051-2066 | |
| 86 | Bob Henderson | 458 | 2045-2060 | |
| 86 | Mike Torrez | 458 | 1967-1984 | |
| 88 | Kevin Eichhorn | 457 | 2014-2030 | |
| 88 | Lefty Grove* | 457 | 1925-1941 | |
| 88 | Juan Marichal* | 457 | 1960-1975 | |
| 91 | Rick Wise | 455 | 1964-1982 | |
| 92 | Mark Buehrle | 450 | 2000-2016 | |
| 93 | Jack Powell | 449 | 1899-1912 | |
| 93 | CC Sabathia | 449 | 2001-2016 | |
| 95 | Jim Perry | 447 | 1959-1975 | |
| 96 | Chris Richardson# | 446 | 2053-2067 | |
| 96 | Cy Young* | 446 | 1899-1911 | |
| 98 | Paul Derringer | 445 | 1931-1945 | |
| 98 | Mao Qiao* | 445 | 2025-2039 | |
| 98 | Danny Salazar | 445 | 2014-2033 |
